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Mikrofalowa, hydrotermalna synteza nanoproszku hydroksyapatytu o strukturze I właściwościach naśladujących bioapatyt

Smoleń Dariusz

Abstract

The aim of this thesis was to develop a method for hydroxyapatite synthesis, which will be fully mimicking biological and physicochemical properties of bio-apatite, which is natural material of bone mineral phase. It is nanometrical, calcium deficient hydroxyapatite. To obtain such material the unique microwave solvothermal synthesis method was applied. This technique is using, as a source of energy, the microwave radiation field with high energy density. As a result the synthesis method of fully crystalline, hydroxyapatite nanopowder was developed. The specific surface area value of obtained material was almost 240 m2/g, average grain size 6 nm and a Ca/P molar ratio equal 1,57, where in case of stoichiometric hydroxyapatite structures the Ca/P molar ratio is equal 1,67. Conducted tests proved significant solubility rate growth and improvement of cell tolerance toward the obtained material, comparing to commercial hydroxyapatite nanopowders. Additionally the developed method enables control of the average grain size and chemical composition of the obtained hydroxyapatite nanoparticles. In consequence it allows to obtain hydroxyapatite with programmed in advance solubility rate in the range from 4,0 to 20,0 mg/dm3, which is range from equal to 5 times higher, than solubility of currently, commercially available hydroxyapatite nanopowders. Obtained hydroxyapatite, thanks to its properties, is perfect candidate for fully resorbable bone implants construction. There is still a lack of bone-compatible materials for construction of tissue-engineered bone products for large bone defects reconstruction. The demand for such materials has increased rapidly in recent years. Despite a number of conducted research, still there is no solution available on the market able to fully reconstruct damaged bone tissue with the appropriate and fully controlled resorption rate. The developed technology and product are protected by two patent application, were presented in four publications in international scientific journals. The nanopowder synthesized by developed method is registered under the GoHAP trademark and manufactured commercially (100 g/day scale) by the Laboratory of Nanostructures IHPP PAS. Currently, the laboratory is negotiating with industrial partner the scaling up of GoHAP production.
Record ID
WUTb6dc7c685e8e4b6d8a4da1368a0fe050
Diploma type
Doctor of Philosophy
Author
Smoleń Dariusz Smoleń Dariusz,, Undefined Affiliation
Title in Polish
Mikrofalowa, hydrotermalna synteza nanoproszku hydroksyapatytu o strukturze I właściwościach naśladujących bioapatyt
Language
(pl) Polish
Certifying Unit
Faculty of Materials Science and Engineering (FMSE)
Discipline
material sciences and engineering / (technology domain) / (technological sciences)
Status
Finished
Start date
27-04-2012
Defense Date
04-07-2014
Title date
04-07-2014
Supervisor
Pages
143
Keywords in English
s
Abstract in English
The aim of this thesis was to develop a method for hydroxyapatite synthesis, which will be fully mimicking biological and physicochemical properties of bio-apatite, which is natural material of bone mineral phase. It is nanometrical, calcium deficient hydroxyapatite. To obtain such material the unique microwave solvothermal synthesis method was applied. This technique is using, as a source of energy, the microwave radiation field with high energy density. As a result the synthesis method of fully crystalline, hydroxyapatite nanopowder was developed. The specific surface area value of obtained material was almost 240 m2/g, average grain size 6 nm and a Ca/P molar ratio equal 1,57, where in case of stoichiometric hydroxyapatite structures the Ca/P molar ratio is equal 1,67. Conducted tests proved significant solubility rate growth and improvement of cell tolerance toward the obtained material, comparing to commercial hydroxyapatite nanopowders. Additionally the developed method enables control of the average grain size and chemical composition of the obtained hydroxyapatite nanoparticles. In consequence it allows to obtain hydroxyapatite with programmed in advance solubility rate in the range from 4,0 to 20,0 mg/dm3, which is range from equal to 5 times higher, than solubility of currently, commercially available hydroxyapatite nanopowders. Obtained hydroxyapatite, thanks to its properties, is perfect candidate for fully resorbable bone implants construction. There is still a lack of bone-compatible materials for construction of tissue-engineered bone products for large bone defects reconstruction. The demand for such materials has increased rapidly in recent years. Despite a number of conducted research, still there is no solution available on the market able to fully reconstruct damaged bone tissue with the appropriate and fully controlled resorption rate. The developed technology and product are protected by two patent application, were presented in four publications in international scientific journals. The nanopowder synthesized by developed method is registered under the GoHAP trademark and manufactured commercially (100 g/day scale) by the Laboratory of Nanostructures IHPP PAS. Currently, the laboratory is negotiating with industrial partner the scaling up of GoHAP production.
Thesis file
  • File: 1
    Smolen.pdf
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Citation count
2

Uniform Resource Identifier
https://repo.pw.edu.pl/info/phd/WUTb6dc7c685e8e4b6d8a4da1368a0fe050/
URN
urn:pw-repo:WUTb6dc7c685e8e4b6d8a4da1368a0fe050

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