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The influence of morphology of the DEP aggregates (diesel exhaust particles) on their transport properties and toxicity

Agata Bożena Penconek

Abstract

The aim of this study was to provide analysis of the DEPs properties, resulting from their size and shape, in the light of various processes having impact on such DEPs during their way starting with their emission as the diesel fumes until their contact with the lung epithelia cells. The hypothesis of this work was that the morphology of soot aggregates (DEPs) affects their transportation properties, and – both directly and indirectly, i.e. as a consequence of their dif-ferent transportation properties – their toxicity. Three different types of DEPs aggregates obtained from three various diesel fuels were used in this study. The deposition of DEPs in a model of human respiratory tract, the transpor-tation of DEPs aggregates through the mucus layer and DEPs influence on human epithelial cells were examined in the light of various DEPs morphology. Moreover, the DEPs filtration efficiency of commercially available individual protection systems was investigated and the more efficient system was presented. The results of the study show that morphology of DEPs influence the transportation prop-erties of the DEPs in the air, i.e. that the deposition of compact DEPs in human lungs is higher, but the amount of such compact DEPs penetrating beyond throat is lower in compari-son to the dendrite-like DEPs. The transportation of DEPs through the mucus layer is slowed down, but it is not stopped, so the DEPs may interact with cells. The morphology of DEPs may influence the rate of endocytosis and, as a consequence, may cause various toxicological effects. The filtration efficiency of individual protection system was 71% – 96%, depending on the morphology of DEPs and the air-flow conditions. Therefore the new system with higher filtration efficiency, regardless of DEPs morphology, has been presented. For the first time such a broad study with the use of real DEPs aggregates was conducted to establish the impact of the DEPs morphology on the processes that govern such DEPs in their interaction with the human body. In addition, the DEPs aggregates' deposition in the human respiratory tract and diffusion through the mucus has never been studied before. Simi-larly, the effectiveness of filtration of personal protective equipment has never been verified. The presented system shows higher filtration efficiency so it gives hope to improve safety and to reduce the likelihood of health complications resulting from exposure to exhausts from diesel engines.
Record ID
WUT9d38256b415d4bed95402426e93430ef
Diploma type
Doctor of Philosophy
Author
Title in Polish
Wpływ morfologii agregatów DEP (Diesel Exhaust Particles) na właściwości transportowe i toksyczność
Title in English
The influence of morphology of the DEP aggregates (diesel exhaust particles) on their transport properties and toxicity
Language
(pl) Polish
Certifying Unit
Faculty of Chemical and Process Engineering (FCPE)
Discipline
chemical engineering / (technology domain) / (technological sciences)
Status
Finished
Start date
26-06-2012
Defense Date
24-06-2014
Supervisor
External reviewers
Rafał Rakoczy Rafał Rakoczy,, External affiliation of publication: Instytut Technologii Chemicznej Nieorganicznej i Inżynierii Środowiska
Krzysztof Warmuziński Krzysztof Warmuziński,, External affiliation of publication: Instytut Inżynierii Chemicznej Polskiej Akademii Nauk
Honored
yes
Pages
153
Internal identifier
DICHP-2337
Keywords in English
soot aggregates, filtration, diffusion, eukaryotic cells
Abstract in English
The aim of this study was to provide analysis of the DEPs properties, resulting from their size and shape, in the light of various processes having impact on such DEPs during their way starting with their emission as the diesel fumes until their contact with the lung epithelia cells. The hypothesis of this work was that the morphology of soot aggregates (DEPs) affects their transportation properties, and – both directly and indirectly, i.e. as a consequence of their dif-ferent transportation properties – their toxicity. Three different types of DEPs aggregates obtained from three various diesel fuels were used in this study. The deposition of DEPs in a model of human respiratory tract, the transpor-tation of DEPs aggregates through the mucus layer and DEPs influence on human epithelial cells were examined in the light of various DEPs morphology. Moreover, the DEPs filtration efficiency of commercially available individual protection systems was investigated and the more efficient system was presented. The results of the study show that morphology of DEPs influence the transportation prop-erties of the DEPs in the air, i.e. that the deposition of compact DEPs in human lungs is higher, but the amount of such compact DEPs penetrating beyond throat is lower in compari-son to the dendrite-like DEPs. The transportation of DEPs through the mucus layer is slowed down, but it is not stopped, so the DEPs may interact with cells. The morphology of DEPs may influence the rate of endocytosis and, as a consequence, may cause various toxicological effects. The filtration efficiency of individual protection system was 71% – 96%, depending on the morphology of DEPs and the air-flow conditions. Therefore the new system with higher filtration efficiency, regardless of DEPs morphology, has been presented. For the first time such a broad study with the use of real DEPs aggregates was conducted to establish the impact of the DEPs morphology on the processes that govern such DEPs in their interaction with the human body. In addition, the DEPs aggregates' deposition in the human respiratory tract and diffusion through the mucus has never been studied before. Simi-larly, the effectiveness of filtration of personal protective equipment has never been verified. The presented system shows higher filtration efficiency so it gives hope to improve safety and to reduce the likelihood of health complications resulting from exposure to exhausts from diesel engines.
Thesis file
  • File: 1
    Penconek.pdf
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Uniform Resource Identifier
https://repo.pw.edu.pl/info/phd/WUT9d38256b415d4bed95402426e93430ef/
URN
urn:pw-repo:WUT9d38256b415d4bed95402426e93430ef

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