Numerical simulation of blood flow through a stented coronary artery

Weronika Kurowska-Nouyrigat

Abstract

Nowadays, cardiac disease is one of the most common cause of death. Each year almost one million of angioplasty interventions and stents implantations are made all over the world. Unfortunately, in 20-30% of cases neointimal proliferations leads to restenosis occurring within the following period of 3-6 months. Three major factors are believed to contribute mostly to the edge restenosis: • mechanical damage of the artery’s wall caused by the stent implantation, • interaction between the stent and the blood constituents, • endothelial growth stimulation by small and oscillating wall shear stress. Assuming that this last factor is particularly important, a numerical model of restenosis based on wall shear stress distribution in the stented artery has been elaborated. Numerical simulations of the pulsatile blood flow and development of in-stent restenosis have been performed and realistic geometric patterns of a progressing lumen reduction have been obtained.
Diploma typeDoctor of Philosophy
Author Weronika Kurowska-Nouyrigat (FPAE)
Weronika Kurowska-Nouyrigat,,
- Faculty of Power and Aeronautical Engineering
Title in EnglishNumerical simulation of blood flow through a stented coronary artery
Languagepl polski
Certifying UnitFaculty of Power and Aeronautical Engineering (FPAE)
Disciplinemechanics / (technology domain) / (technological sciences)
Defense Date21-12-2010
Supervisor Jacek Szumbarski (FPAE / IAAM)
Jacek Szumbarski,,
- The Institute of Aeronautics and Applied Mechanics

Internal reviewers Andrzej Styczek (FPAE / IAAM)
Andrzej Styczek,,
- The Institute of Aeronautics and Applied Mechanics
External reviewers Jacek Waniewski - [Instytut Biocybernetyki i Inżynierii Biomedycznej im. Macieja Nałęcza Polskiej Akademii Nauk (IBIB) [Polish Academy of Sciences (PAN)]]
Jacek Waniewski,,
-
- Instytut Biocybernetyki i Inżynierii Biomedycznej im. Macieja Nałęcza Polskiej Akademii Nauk
Pages118
Internal identifierMEL; D-147
Keywords in Englishxxx
Abstract in EnglishNowadays, cardiac disease is one of the most common cause of death. Each year almost one million of angioplasty interventions and stents implantations are made all over the world. Unfortunately, in 20-30% of cases neointimal proliferations leads to restenosis occurring within the following period of 3-6 months. Three major factors are believed to contribute mostly to the edge restenosis: • mechanical damage of the artery’s wall caused by the stent implantation, • interaction between the stent and the blood constituents, • endothelial growth stimulation by small and oscillating wall shear stress. Assuming that this last factor is particularly important, a numerical model of restenosis based on wall shear stress distribution in the stented artery has been elaborated. Numerical simulations of the pulsatile blood flow and development of in-stent restenosis have been performed and realistic geometric patterns of a progressing lumen reduction have been obtained.
Thesis file
Kurowska-Nouyrigat.pdf 8.04 MB

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