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## Determination of selected ingredients in ciosmeceuticals

### Kinga Moskal

#### Abstract

Introduction Cosmeceuticals are a hybrid of pharmaceutical and cosmetics [1]. These products have very important medicinal properties because they contain different biologically active ingredients for example: organic dyes, vitamins, organic acids and derivatives, cumarin, aldehydes, lactones and ketones [2]. Skin penetration accelerators (such as: glycol or urea) are added into cosmeceuticals to improve transepidermal transport [3]. A large variety of ingredients in cosmetics products is a challenge for chemical analysis [4]. It is important to create selective and effective method of separation. In literature there are a few publications about separation and determination ingredients in cosmeceuticals moreover, some authors describe very complicated analytical procedures [5], [6], [7]. Results and Discussion Separation method like LLE (liquid – liquid extraction), which is used to isolate different ingredients from cosmeceuticals, is not effective. Emulsion is obtained during shaking and phases separation is very difficult. According to that, the main aim of my work was to create a selective and static method to isolate ingredients from cosmeceuticals before the quantity analysis. Glass tubes were constructed. Into the tubes there were two water phases and between them there was an organic solvent, called a liquid membrane. Two different shapes of the tubes (like W and U) depend on density of the liquid membrane. Depending on the contents of liquid membrane and pH of water phases the efficiency of that process was measured. Moreover, contents of surfactants in cosmetics was checked. On the basis of the results of the membrane process we can separate biological active ingredients from surfactants. This was confirmed by two other methods: solid phase extraction (SPE) and two – phase (two było skreślone przez Pana, a chodzi mi tu o dwufazowe miareczkowanie) titration. That membrane separation method was used to isolate biologically active ingredients from: soaps, creams, shampoo and lotions and determine them by high pressure liquid chromatography (HPLC). Conclusions A Selective, cheap, static, membrane method was designed to isolate biologically active ingredients from cosmeceuticals. This technique was used to the separation of analytes from surfactants and other cosmetics matrix ingredients. Moreover, some biological active compounds was determined by HPLC.
Record ID
WUT6aff57240ed44a61824553f1e858e69c
Diploma type
Master of Science
Author
Kinga Moskal Kinga Moskal,, Undefined Affiliation
Title in Polish
Supervisor
Norbert Obarski (FC/CAC) Norbert Obarski,, Chair Of Analytical Chemistry (FC/CAC)Faculty of Chemistry (FC)
Certifying unit
Faculty of Chemistry (FC)
Affiliation unit
Chair Of Analytical Chemistry (FC/CAC)
Study subject / specialization
, Technologia Chemiczna
Language
(pl) Polish
Status
Finished
Defense Date
20-06-2012
Issue date (year)
2012
Keywords in Polish
-
Keywords in English
-
Abstract in Polish
urn:pw-repo:WUT6aff57240ed44a61824553f1e858e69c