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Studies of mass transfer trough a model mucus layer

Agnieszka Maria Dąbrowska

Abstract

The graduate thesis is focused on impact of the rheology of model mucus (tragacanth gum) on mass transfer kinetics. Aim of the research was to develop a model system to study drug transport through a bronchial mucus in pathological states. The theoretical part of the thesis presents background information on human respiratory system function and structure, and aerosol therapy as the most effective method of treatment of diseases in the respiratory system. It also focuses on issues related to the properties and function of airway mucus, and the diseases related to the change in mucus rheology. Basic information about the transport of drugs in the human body is also briefly discussed. The experimental part describes the concept of proposed measuring system, its components (measuring cell, magnetic stirrer, a spectrophotometer, viscometer), and research materials (i.e., gum tragacanth as a model component of mucus, methylene blue as a substance transferred). Research methodology is presented, in which shows the influence of effective viscosity of mucus (at three concentrations: 0.1%, 0.2% and 1%) on the kinetics of mass transport through the layer. The study confirmed that the increase in the effective viscosity of mucus decreases nonlinearly the maximum rate of mass transport. The conclusions of the research indicate that the use of inhalation mucolytics (ie. medicines used to fluidize the mucus) should result in improving the penetration of drugs into the cells of the bronchial epithelium.
Record ID
Diploma type
Master of Science
Author
Agnieszka Maria Dąbrowska (FCPE) Agnieszka Maria Dąbrowska,, Faculty of Chemical and Process Engineering (FCPE)
Title in Polish
Pomiary transportu masy przez modelową warstwę śluzu
Supervisor
Tomasz Robert Sosnowski (FCPE/CIPE) Tomasz Robert Sosnowski,, Chair of Integrated Process Engineering (FCPE/CIPE)Faculty of Chemical and Process Engineering (FCPE)
Certifying unit
Faculty of Chemical and Process Engineering (FCPE)
Affiliation unit
Chair of Integrated Process Engineering (FCPE/CIPE)
Study subject / specialization
, Inżynieria Chemiczna i Procesowa
Language
(pl) Polish
Status
Finished
Defense Date
10-01-2012
Issue date (year)
2012
Pages
55
Internal identifier
DICHP-2059
Reviewers
Tomasz Robert Sosnowski (FCPE/CIPE) Tomasz Robert Sosnowski,, Chair of Integrated Process Engineering (FCPE/CIPE)Faculty of Chemical and Process Engineering (FCPE) Piotr Kuran (FCPE/DSP) Piotr Kuran,, Department of Separation Processes (FCPE/DSP)Faculty of Chemical and Process Engineering (FCPE)
Keywords in Polish
-
Keywords in English
-
Abstract in Polish
File
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Agnieszka Dąbrowska_201075.pdf
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Identyfikator pracy APD: 2910

Uniform Resource Identifier
urn:pw-repo:WUT33536c8ad9384dbfa49583117e85479d