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## Evaluation of the effectiveness of active ingredients in make-up cosmetics

### Monika Kotlewska

#### Abstract

The aim of this thesis was to investigate the influence of pigments: titanium dioxide CI 77891, iron oxide 77492, iron oxide CI 77491 and iron oxide CI 77499, on the concentration of niacinamide in an aqueous solution and in an emulsion, and also on the effectiveness of niacinamide permeation through the model lipid membranes. On the basis of the collected literature, basic information about decorative cosmetics, cosmetic emulsions and methods of their production, skin structure, methods of testing chemical compounds permeation through the model lipids membranes, liposomes and basic methods of their preparation and modification have been presented. In addition, selected pigments and active ingredients that are commonly used in cosmetics have been described. The experimental part is composed of 3 stages: in the first two of them the effect of selected pigments on the concentration of niacinamide in an aqueous solution and in an emulsion was examined. In the third the effect of selected pigments on the effectiveness of niacinamide permeation from aqueous solution through the model lipid membranes in Flynn’s cells was investigated. Despite the ambiguous results, the initial studies on titanium dioxide suggest that it may catalyse to some extent the decomposition of vitamin B3, but it happens so slowly that changes can not be observed at higher concentrations of niacinamide (0,5%) in two weeks. Investigation on the effect of pigments on the concentration of niacinamide in emulsions also did not show significant changes over two weeks. An experiment investigating the effect of pigments on the effectiveness of vitamin B3 permeation through the model lipid membranes did not give conclusive results. The measurements suggest that pigments may reduce the efficiency of this permeation (〖Kp〗_bp>〖Kp〗_zp), but the variance of the obtained results does not allow to draw clear conclusions.
Diploma type
Engineer's / Bachelor of Science
Diploma type
Engineer's thesis
Author
Monika Kotlewska (FC) Monika Kotlewska,, Faculty of Chemistry (FC)
Title in Polish
Ocena efektywności działania substancji aktywnych w kosmetykach do makijażu
Supervisor
Monika Wielechowska (FC/CDSB) Monika Wielechowska,, Chair of Drug and Cosmetics Biotechnology (FC/CDSB)Faculty of Chemistry (FC)
Certifying unit
Faculty of Chemistry (FC)
Affiliation unit
Chair of Drug and Cosmetics Biotechnology (FC/CDSB)
Study subject / specialization
, Technologia Chemiczna
Language
(pl) Polish
Status
Finished
Defense Date
01-02-2019
Issue date (year)
2019
Reviewers
Robert Ziółkowski (FC/CMB) Robert Ziółkowski,, Chair of Medical Biotechnology (FC/CMB)Faculty of Chemistry (FC) Monika Wielechowska (FC/CDSB) Monika Wielechowska,, Chair of Drug and Cosmetics Biotechnology (FC/CDSB)Faculty of Chemistry (FC)
Keywords in Polish
niacynamid, pigmenty, kosmetyki do makijażu, badanie przenikania, komory Flynna, membrana lipidowa, liposomy, fosfatydylocholina
Keywords in English
niacinamide, pigments, make-up cosmetics, permeation, Flynn’s cells, lipid membrane, liposomes, phosphatidylcholine
Abstract in Polish
File
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praca_inż-Kotlewska_Monika-278422.pdf
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Identyfikator pracy APD: 29924

Uniform Resource Identifier
https://repo.pw.edu.pl/info/bachelor/WUTb360a8c3159f4052ba907272c4be9790/
URN
urn:pw-repo:WUTb360a8c3159f4052ba907272c4be9790

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