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## Selection of material for surface treatment of bone implants with antibiotics

### Paweł Bronowicz

#### Abstract

The purpose of the study was to obtain biodegradable, polymer films with antibiotics and examine the impact of their physicochemical and degradation properties on the drug release rate. For this purpose, for each of the three drugs studied (Ciproflaxin HCl, Cefuroxime and Ciproflaxin, 98%) there were five samples from various materials prepared: PLA/PCL 70/30, PDLG 50/50, PLG 85/15, PCL 80000 and PLA. The study has been divided into two parts: the description of the initial material and the examination of the material during degradation. The chemical structure of the materials obtained has been measured by the Fourier infrared spectroscopy, the characteristic temperature and crystallinity have been tested by differential scanning calorimetry and the molecular mass has been identified by the gel chromatography. The research has shown the lack of versatile carrier for the drug. The release rate depends not only on the polymer but also on the drug used, however almost all cases have shown the mechanism of diffusion based drug release. For the water-soluble drugs, the degradation rate of the carrier has been proven to be the key factor – the faster the polymer degrades, the more drug is being released. Water absorption also plays a great role, e.g. the PDLG 50/50, in which the parameter reached about 20%, has shown the fastest release over time. Due to its use in bone implants, the PDLG 50/50 appears to be the best polymer as it releases a fair amount of drug in a short period of time. This could prevent any potential infections right after the surgery and would be able to protect the tissue adjacent to the implant from the inflammation resulting from the immune response. The hydrophobic antibiotics are easier to release from crystalline, slowly degrading polymers.
Diploma type
Engineer's / Bachelor of Science
Diploma type
Engineer's thesis
Author
Paweł Bronowicz (FMSE) Paweł Bronowicz,, Faculty of Materials Science and Engineering (FMSE)
Title in Polish
Dobór materiału do powierzchniowego wzbogacania implantów kostnych w antybiotyki
Supervisor
Wojciech Święszkowski (FMSE/DMD) Wojciech Święszkowski,, Division of Materials Design (FMSE/DMD)Faculty of Materials Science and Engineering (FMSE)
Certifying unit
Faculty of Materials Science and Engineering (FMSE)
Affiliation unit
Division of Materials Design (FMSE/DMD)
Study subject / specialization
, Inżynieria Materiałowa
Language
(pl) Polish
Status
Finished
Defense Date
11-02-2019
Issue date (year)
2019
Internal identifier
IM-D.002354
Reviewers
Anna Boczkowska (FMSE/DSMP) Anna Boczkowska,, Division of Ceramic Materials and Polymers (FMSE/DSMP)Faculty of Materials Science and Engineering (FMSE) Wojciech Święszkowski (FMSE/DMD) Wojciech Święszkowski,, Division of Materials Design (FMSE/DMD)Faculty of Materials Science and Engineering (FMSE)
Keywords in Polish
Systemy uwalniania leków, polimery biodegradowalne, cyprofloksacyna, cefuroksym, poliestry, antybiotyki, modele uwalniania leków
Keywords in English
Drug delivery systems, biodegradable polymers, ciprofloxacin, cefuroxime, antibiotics, models for drug release
Abstract in Polish
File
• File: 1
dobór_materiały_do_powierzchniowego_wzbogacenia_imlantów_kostnych_w_antybiotyki.pdf
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Local fields
Identyfikator pracy APD: 30770

Uniform Resource Identifier
https://repo.pw.edu.pl/info/bachelor/WUTa353b2db30c34be29e7a0d842198ec43/
URN
urn:pw-repo:WUTa353b2db30c34be29e7a0d842198ec43

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