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## Influence of geometry on the mass transfer rate of substance in simulated biomedical systems

### Weronika Jaworska

#### Abstract

Cardiovascular diseases are a serious problem, which is the main cause of mortality in Poland. Therefore, methods of cardiovascular disease treatment are still being developed and improved. One of the most effective medical procedures used to dilate blood vessels is the use of stents, especially drug releasing stents (DES Drug Eluting Stents). The theoretical part describes the individual stages of drug transport in the human body, determined by the LADME model. Subsequent generations of stents have been characterized. It also includes a thorough review of literature in terms of experimental methods of drug release from stents. Three articles on this subject were presented, with particular emphasis on: the active substance used, the method of covering stents with polymers and the study of the release of the active substance from stents. The active substance used in the experiments was cochineal red, which is characterized by high molecular weight, similar to the weight of active substances of drugs, and its concentration changes can easily be determined by spectrophotometric method. In the first part of the experiment the possibility of controlled immersion coating of stents with polymers containing low concentration of cochineal red was investigated. The following polymers were selected: agar, gelatin and dextran. Another test was the release of the active substance from these stents, carried out with the "leaching" method. The best results of coating and release of the active substance from the polymer layer were obtained in the case of agar. In the second part of the experiments the main aim of the study was to compare two systems of different geometry: vertical (cylindrical ring shape) and horizontal (flat). A comparison of the rate of cochineal red diffusion from the gelatin layer and from agar allowed to select a more suitable hydrogel, which turned out to be agar. Two systems with opposite "directions" of component transport were also considered: from agar saturated with cochineal red (simulating component transport from a blood vessel to blood) and from cochineal red solution to agar (imitating component transport from blood to blood vessel). Experiments showed a similar transport rate in both geometries. Higher transport intensity of the component in the horizontal system was observed in the case of migration of the active substance from the hydrogel layer to the flowing liquid. In the case of the vertical system, the results proving a greater change in the weight of the substance in the system, when cochineal red diffused from the solution to the agar layer, were obtained. The following thesis belongs to a broader scope of research on drug migration in systems simulating biomedical systems.
Diploma type
Engineer's / Bachelor of Science
Diploma type
Engineer's thesis
Author
Weronika Jaworska (FCPE) Weronika Jaworska,, Faculty of Chemical and Process Engineering (FCPE)
Title in Polish
Supervisor
Anna Adach (FCPE/DPKT) Anna Adach,, Department of Process Kinetics and Thermodynamics (FCPE/DPKT)Faculty of Chemical and Process Engineering (FCPE)
Certifying unit
Faculty of Chemical and Process Engineering (FCPE)
Affiliation unit
Department of Process Kinetics and Thermodynamics (FCPE/DPKT)
Study subject / specialization
, Inżynieria Chemiczna i Procesowa
Language
(pl) Polish
Status
Finished
Defense Date
05-02-2019
Issue date (year)
2019
Pages
56
Internal identifier
DICHP-2861
Reviewers
Katarzyna Dąbkowska (FCPE/DBBE) Katarzyna Dąbkowska,, Department of Biotechnology and Bioprocess Engineering (FCPE/DBBE)Faculty of Chemical and Process Engineering (FCPE) Anna Adach (FCPE/DPKT) Anna Adach,, Department of Process Kinetics and Thermodynamics (FCPE/DPKT)Faculty of Chemical and Process Engineering (FCPE)
Keywords in Polish
Keywords in English
drug eluting stensts, mass transport, drug liberation, geometry system, biomedical system
Abstract in Polish
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Weronika_Jaworska_277558.pdf
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Identyfikator pracy APD: 26358

Uniform Resource Identifier
https://repo.pw.edu.pl/info/bachelor/WUT575bb535d94f44a8b7ea896a064801c2/
URN
urn:pw-repo:WUT575bb535d94f44a8b7ea896a064801c2

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