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## Characterization of rheological properties of artificial mucus in the presence of selected nanoparticles

### Karina Flasińska

#### Abstract

Nanoparticles, both of anthropogenic origin as well as those of natural origin, are commonly found in suspended dust getting into the airways in the process of breathing. When entering the body, they contact the mucus layer, which is the primary protective barrier against harmful substances. This paper focuses on investigating the effect of the depositing of selected nanostructures in the mucus layer. The theoretical part focused on determining the composition and function of mucus in the human body, characterized rheological properties of natural mucus and factors that may disturb its rheology. Then, various models of artificial mucus were reviewed and a model for further use in the studies was selected. The source of nanostructures in the atmosphere was also considered. The experimental part determined the effect of natural origin nanoparticles (Arizona desert dust particles) and anthropogenic origin nanoparticles (diesel exhaust particles obtained as a result of burning Verva ON diesel) on rheological properties of artificial mucus solutions with different mucin content (5% by weight, 10% by weight and 15% by weight) at two different temperatures (36.6°C and 40.0°C). The measurements were made using an oscillating rheometer. As a result, flow curves and graphs of apparent viscosity as a function of shear rate were obtained. In the case of 5% by weight solution and 10% by weight solution, as a result of the addition of both desert dust and diesel exhaust particles, a decrease in the viscosity of mucus was observed. In the case of 15% by weight solution, Arizona particles caused an increase in viscosity, while Verva particles caused its decline. The results obtained for the 15% by weight solution require further research to confirm and clarify this effect. Measurements performed at both temperatures gave very similar results, with the difference that the viscosities obtained at 40.0°C were lower than those at 36.6°C. However, in both cases, it can be concluded that the addition of nanostructures affects the rheological properties of the model mucus, which may lead to the disruption of the function of mucus layer.
Diploma type
Engineer's / Bachelor of Science
Diploma type
Engineer's thesis
Author
Karina Flasińska (FCPE) Karina Flasińska,, Faculty of Chemical and Process Engineering (FCPE)
Title in Polish
Charakterystyka właściwości reologicznych sztucznego śluzu w obecności wybranych nanocząstek
Supervisor
Agata Bożena Penconek (FCPE/CIPE) Agata Bożena Penconek,, Chair of Integrated Process Engineering (FCPE/CIPE)Faculty of Chemical and Process Engineering (FCPE)
Certifying unit
Faculty of Chemical and Process Engineering (FCPE)
Affiliation unit
Chair of Integrated Process Engineering (FCPE/CIPE)
Study subject / specialization
, Inżynieria Chemiczna i Procesowa
Language
(pl) Polish
Status
Finished
Defense Date
04-02-2019
Issue date (year)
2019
Pages
41
Internal identifier
DICHP-2854
Reviewers
Agata Bożena Penconek (FCPE/CIPE) Agata Bożena Penconek,, Chair of Integrated Process Engineering (FCPE/CIPE)Faculty of Chemical and Process Engineering (FCPE) Katarzyna Dąbkowska (FCPE/DBBE) Katarzyna Dąbkowska,, Department of Biotechnology and Bioprocess Engineering (FCPE/DBBE)Faculty of Chemical and Process Engineering (FCPE)
Keywords in Polish
sztuczny śluz oskrzelowy, reologia, nanocząstki
Keywords in English
artificial bronchial mucus, rheology, nanoparticles
Abstract in Polish
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Identyfikator pracy APD: 26293
urn:pw-repo:WUT4827f9f5419e4c409827493105366971