Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency

Nel Dąbrowska-Leonik , Ewa Bernatowska , Małgorzata Pac , Wiktor Filipiuk , Jan Mulawka , Barbara Pietrucha , Edyta Heropolitańska-Pliszka , Katarzyna Bernat-Sitarz , Beata Wolska-Kuśnierz , Bożena Mikołuć

Abstract

Purpose The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination.

Materials and method The study involved 730 patients with recurrent respiratory infections. The concentration of 25-hydroxyvitamin D (25(OH)D), immunoglobulins G, A and M, anti-HBs was determined.

Results The tests showed that 11% of patients presented IgG levels below the age related reference values. Children with reduced IgG concentration were also found to have significantly lower vitamin D concentrations in comparison to children with normal IgG. Vitamin D deficiency was observed in schoolchildren between 7 and 18 years of age. No correlation was found between 25(OH)D concentration and Hbs antibody levels.

Conclusions An investigation of a large group of patients who have recurrent infection found patients with IgG deficiency to whom special proceeding have to be performed: 1. Significantly lower vitamin D concentration observed in the group of children with IgG deficiency implicated in long-lasting monitoring of vitamin D level require adding to the practice guidelines for Central Europe 2013. 2. Intervention treatment with suitable doses of vitamin D to clarified metabolism of vitamin D has to be plan for children with IgG deficiency and significant lower vitamin D concentration.

Author Nel Dąbrowska-Leonik
Nel Dąbrowska-Leonik,,
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, Ewa Bernatowska
Ewa Bernatowska,,
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, Małgorzata Pac
Małgorzata Pac,,
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, Wiktor Filipiuk II
Wiktor Filipiuk,,
- The Institute of Computer Science
, Jan Mulawka II
Jan Mulawka,,
- The Institute of Computer Science
, Barbara Pietrucha
Barbara Pietrucha,,
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, Edyta Heropolitańska-Pliszka
Edyta Heropolitańska-Pliszka,,
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, Katarzyna Bernat-Sitarz
Katarzyna Bernat-Sitarz,,
-
, Beata Wolska-Kuśnierz
Beata Wolska-Kuśnierz,,
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, Bożena Mikołuć
Bożena Mikołuć,,
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Journal seriesAdvances in Medical Sciences, ISSN 1896-1126
Issue year2018
Vol63
No1
Pages173-178
Publication size in sheets0.5
Keywords in EnglishVitamin D; Immunoglobulins; Ig G; Immune system
DOIDOI:10.1016/j.advms.2017.08.001
URL http://www.sciencedirect.com/science/article/pii/S1896112617300573
Languageen angielski
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1-s2.0-S1896112617300573-main.pdf 580.84 KB
Score (nominal)15
ScoreMinisterial score [Punktacja MNiSW] = 15.0, 14-11-2017, ArticleFromJournal
Ministerial score (2013-2016) [Punktacja MNiSW (2013-2016)] = 15.0, 14-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor [Impact Factor WoS]: 2016 = 1.364 (2) - 2016=1.358 (5)
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