Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency
Nel Dąbrowska-Leonik , Ewa Bernatowska , Małgorzata Pac , Wiktor Filipiuk , Jan Mulawka , Barbara Pietrucha , Edyta Heropolitańska-Pliszka , Katarzyna Bernat-Sitarz , Beata Wolska-Kuśnierz , Bożena Mikołuć
Purpose The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination.
Materials and method The study involved 730 patients with recurrent respiratory infections. The concentration of 25-hydroxyvitamin D (25(OH)D), immunoglobulins G, A and M, anti-HBs was determined.
Results The tests showed that 11% of patients presented IgG levels below the age related reference values. Children with reduced IgG concentration were also found to have significantly lower vitamin D concentrations in comparison to children with normal IgG. Vitamin D deficiency was observed in schoolchildren between 7 and 18 years of age. No correlation was found between 25(OH)D concentration and Hbs antibody levels.
Conclusions An investigation of a large group of patients who have recurrent infection found patients with IgG deficiency to whom special proceeding have to be performed: 1. Significantly lower vitamin D concentration observed in the group of children with IgG deficiency implicated in long-lasting monitoring of vitamin D level require adding to the practice guidelines for Central Europe 2013. 2. Intervention treatment with suitable doses of vitamin D to clarified metabolism of vitamin D has to be plan for children with IgG deficiency and significant lower vitamin D concentration.
|Journal series||Advances in Medical Sciences, ISSN 1896-1126|
|Publication size in sheets||0.5|
|Keywords in English||Vitamin D; Immunoglobulins; Ig G; Immune system|
|Score|| = 15.0, 14-11-2017, ArticleFromJournal|
= 15.0, 14-11-2017, ArticleFromJournal
|Publication indicators||: 2016 = 1.364 (2) - 2016=1.358 (5)|
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