Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency

Nel Dąbrowska-Leonik , Ewa Bernatowska , Małgorzata Pac , Wiktor Filipiuk , Jan Mulawka , Barbara Pietrucha , Edyta Heropolitańska-Pliszka , Katarzyna Bernat-Sitarz , Beata Wolska-Kuśnierz , Bożena Mikołuć


Purpose The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination.

Materials and method The study involved 730 patients with recurrent respiratory infections. The concentration of 25-hydroxyvitamin D (25(OH)D), immunoglobulins G, A and M, anti-HBs was determined.

Results The tests showed that 11% of patients presented IgG levels below the age related reference values. Children with reduced IgG concentration were also found to have significantly lower vitamin D concentrations in comparison to children with normal IgG. Vitamin D deficiency was observed in schoolchildren between 7 and 18 years of age. No correlation was found between 25(OH)D concentration and Hbs antibody levels.

Conclusions An investigation of a large group of patients who have recurrent infection found patients with IgG deficiency to whom special proceeding have to be performed: 1. Significantly lower vitamin D concentration observed in the group of children with IgG deficiency implicated in long-lasting monitoring of vitamin D level require adding to the practice guidelines for Central Europe 2013. 2. Intervention treatment with suitable doses of vitamin D to clarified metabolism of vitamin D has to be plan for children with IgG deficiency and significant lower vitamin D concentration.

Author Nel Dąbrowska-Leonik
Nel Dąbrowska-Leonik,,
, Ewa Bernatowska
Ewa Bernatowska,,
, Małgorzata Pac
Małgorzata Pac,,
, Wiktor Filipiuk (FEIT / IN)
Wiktor Filipiuk,,
- The Institute of Computer Science
, Jan Mulawka (FEIT / IN)
Jan Mulawka,,
- The Institute of Computer Science
, Barbara Pietrucha
Barbara Pietrucha,,
, Edyta Heropolitańska-Pliszka
Edyta Heropolitańska-Pliszka,,
, Katarzyna Bernat-Sitarz
Katarzyna Bernat-Sitarz,,
, Beata Wolska-Kuśnierz
Beata Wolska-Kuśnierz,,
, Bożena Mikołuć
Bożena Mikołuć,,
Journal seriesAdvances in Medical Sciences, ISSN 1896-1126, (A 15 pkt)
Issue year2018
Publication size in sheets0.5
Keywords in EnglishVitamin D; Immunoglobulins; Ig G; Immune system
ASJC Classification2700 General Medicine
projectDevelopment of new algorithms in the areas of software and computer architecture, artificial intelligence and information systems and computer graphics . Project leader: Arabas Jarosław, , Phone: +48 22 234 7432, start date 01-08-2018, planned end date 31-12-2018, II/2018/DS/1, Implemented
WEiTI Działalność statutowa
Languageen angielski
1-s2.0-S1896112617300573-main.pdf 580.84 KB
Score (nominal)15
ScoreMinisterial score = 15.0, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.635; WoS Impact Factor: 2017 = 2.064 (2) - 2017=1.681 (5)
Citation count*
Share Share

Get link to the record

* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.