Well-defined graphene oxide as a potential component in lung cancer therapy

Agnieszka Żuchowska , Elżbieta Jastrzębska , Marta Mazurkiewicz-Pawlicka , Artur Małolepszy , Leszek Stobiński , Maciej Trzaskowski , Zbigniew Brzózka

Abstract

Background:Graphene oxide (GO) has unique physical and chemical properties that can be used in anticancer therapy - especially as a drug carrier. Graphene oxide due to the presence of several hybrid layers of carbon atoms (sp2), has a large surface for highly efficient drug loading. In addition, GO with a large number of carboxyl, hydroxyl and epoxy groups on its surface, can charge various drug molecules through covalent bonds, hydrophobic interactions, hydrogen bonds and electrostatic interactions.Objective:The aim of our work was to evaluate a possibility of future use of graphene oxide as an anticancer drug carrier.Method:In this paper, we present GO synthesis and characterization as well as study of its biological properties. The cytotoxic effect of well-defined graphene oxide was tested on both carcinoma and non-malignant cells isolated from the same organ, what is not often presented in the literature.Results:The performed research confirmed that GO in high concentrations (> 300 µgmL-1) selectively decreased viability of cancer cell line. Additionally, we showed that the GO flakes have high affinity to cancer cells nucleus what influence their metabolism (inhibition of cancer cell proliferation). Moreover, we have proved that GO in high concentrations can cause cell membrane damage and generate reactive oxygen species on a low level mainly in cancer cells.Conclusion:The proposed GO could be useful in anticancer therapy. High concentration of GO selectively cause the death of tumor cells, whereas GO with low concentration could be a potential material for anticancer drug loading.
Author Agnieszka Żuchowska (FC / CMB)
Agnieszka Żuchowska,,
- Chair of Medical Biotechnology
, Elżbieta Jastrzębska (FC / CMB)
Elżbieta Jastrzębska,,
- Chair of Medical Biotechnology
, Marta Mazurkiewicz-Pawlicka (FCPE / DSP)
Marta Mazurkiewicz-Pawlicka,,
- Department of Separation Processes
, Artur Małolepszy (FCPE / DSP)
Artur Małolepszy,,
- Department of Separation Processes
, Leszek Stobiński (FCPE / GL)
Leszek Stobiński,,
- WUT Grafen Laboratory
, Maciej Trzaskowski (CAMT)
Maciej Trzaskowski ,,
- The Centre for Advanced Materials and Technologies
, Zbigniew Brzózka (FC / CMB)
Zbigniew Brzózka,,
- Chair of Medical Biotechnology
Journal seriesCurrent Cancer Drug Targets, ISSN 1568-0096, e-ISSN 1873-5576
Issue year2020
Vol20
No1
Pages47-58
Publication size in sheets0.55
Keywords in Englishgraphene oxide, cytotoxicity, drug carrier, graphene, graphene-based materials, lung cancer
ASJC Classification1306 Cancer Research; 3002 Drug Discovery; 3004 Pharmacology
DOIDOI:10.2174/1568009619666191021113807
Languageen angielski
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 10-06-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.535; WoS Impact Factor: 2018 = 2.72 (2) - 2018=3.238 (5)
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