Contrary effect of two types of spatial distribution (diffuse versus marginal) of CD8-positive lymphocytes on clinical outcome in melanoma patients
Piotr Donizy , Przemysław Biecek , M. Kaczorowski , Agnieszka Halon , Adam Maciejczyk , Rafal Matkowski
Malignant melanoma is one of the most immunogenic human neoplasms; immune response of the host impedes disease development, especially at its early phase. Immunohistochemical staining was used to visualize CD4+ and CD8+ T cells and to examine the prognostic significance of their proportion and spatial distribution within 68 melanoma primary tumors with non-brisk and brisk tumor-infiltrating lymphocytes (TILs). We revealed that a high ratio of CD8+ cells among TILs and their diffuse distribution were associated with longer melanoma-specific survival. Moreover, diffuse localization of CD8+ lymphocytes correlated with a significantly longer disease-free survival. Neither the percentage nor spatial distribution of CD4+ TILs influenced patient survival. Our results underscore the role of TILs in melanoma pathobiology. We demonstrated that the clinical outcome in skin melanoma patients is related to the phenotypic composition of TILs and their spatial relation to the tumor mass.
|Journal series||International Journal of Clinical and Experimental Pathology, ISSN 1936-2625|
|Score|| = 20.0, 30-01-2020, ArticleFromJournal|
= 25.0, 30-01-2020, ArticleFromJournal
|Publication indicators||= 1; = 0; : 2016 = 0.624; : 2016 = 1.706 (2) - 2016=1.779 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.