Contrary effect of two types of spatial distribution (diffuse versus marginal) of CD8-positive lymphocytes on clinical outcome in melanoma patients

Piotr Donizy , Przemysław Biecek , M. Kaczorowski , Agnieszka Halon , Adam Maciejczyk , Rafal Matkowski


Malignant melanoma is one of the most immunogenic human neoplasms; immune response of the host impedes disease development, especially at its early phase. Immunohistochemical staining was used to visualize CD4+ and CD8+ T cells and to examine the prognostic significance of their proportion and spatial distribution within 68 melanoma primary tumors with non-brisk and brisk tumor-infiltrating lymphocytes (TILs). We revealed that a high ratio of CD8+ cells among TILs and their diffuse distribution were associated with longer melanoma-specific survival. Moreover, diffuse localization of CD8+ lymphocytes correlated with a significantly longer disease-free survival. Neither the percentage nor spatial distribution of CD4+ TILs influenced patient survival. Our results underscore the role of TILs in melanoma pathobiology. We demonstrated that the clinical outcome in skin melanoma patients is related to the phenotypic composition of TILs and their spatial relation to the tumor mass.

Author Piotr Donizy - [Wroclaw Medical University]
Piotr Donizy,,
, Przemysław Biecek (FMIS / DCSDCAM)
Przemysław Biecek,,
- Department of CAD/CAM Systems Design and Computer-Aided Medicine
, M. Kaczorowski
M. Kaczorowski,,
, Agnieszka Halon - [Wroclaw Medical University]
Agnieszka Halon,,
, Adam Maciejczyk - [Lower Silesian Cancer Center]
Adam Maciejczyk,,
, Rafal Matkowski - [Wroclaw Medical University]
Rafal Matkowski,,
Journal seriesInternational Journal of Clinical and Experimental Pathology, ISSN 1936-2625
Issue year2016
ASJC Classification2722 Histology; 2734 Pathology and Forensic Medicine
Languageen angielski
Score (nominal)25
Score sourcejournalList
ScoreMinisterial score = 20.0, 30-01-2020, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, 30-01-2020, ArticleFromJournal
Publication indicators Scopus Citations = 1; WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.624; WoS Impact Factor: 2016 = 1.706 (2) - 2016=1.779 (5)
Citation count*
Share Share

Get link to the record

* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Are you sure?