Electrochemically controlled release of molecular guests from redox responsive polymeric multilayers and devices

Jing Song , Dominik Jańczewski , Yujie Ma , Lennard van Ingen , Ching Ee Sim , Qianling Goh , Jianwei Xu , G. Julius Vancso

Abstract

A novel platform technology for a tunable molecular payload release, employing complex release profiles, from electrode surfaces is reported. Organometallic poly(ferrocenylsilanes) (PFSs), featuring redox responsive ferrocene units in their main chain, are used as a carrier medium to prepare thin films by the layer-by-layer (LbL) method for redox triggered delivery. These films form the active component of the device. The release of guest molecules from PFS multilayer templates was monitored by fluorescence spectroscopy by varying the supporting electrolyte, the ionic strength of electrolyte, redox inactive components, blocking layers and the molar mass of the polymer. Incorporation of Dextran–TRITC and Dextran–Alexa 488 dye molecules into PFS multilayers, at various depths of the film, enabled tuning of the release profiles with different release kinetics for the each component. Composite multilayers encompassing dual redox and pH responsive polyelectrolytes show double responsive control over the dye release. Finally a device was build featuring the combination of a microelectrode array (MEA) and PFS multilayers to demonstrate area addressable pulsed release for potential applications.
Author Jing Song - [A-Star, Institute of Materials Research and Engineering]
Jing Song,,
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, Dominik Jańczewski (FC / LTP) - [Institute of Materials Research and Engineering]
Dominik Jańczewski,,
- Laboratory Of Technological Processes
- Institute of Materials Research and Engineering
, Yujie Ma - [Radboud University Nijmegen]
Yujie Ma,,
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, Lennard van Ingen - [MESA Institute for Nanotechnology]
Lennard van Ingen,,
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, Ching Ee Sim - [Nanyang Technological University]
Ching Ee Sim,,
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, Qianling Goh - [Nanyang Technological University]
Qianling Goh,,
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, Jianwei Xu - [A-Star, Institute of Materials Research and Engineering]
Jianwei Xu,,
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, G. Julius Vancso - [MESA Institute for Nanotechnology]
G. Julius Vancso,,
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Journal seriesEuropean Polymer Journal, ISSN 0014-3057
Issue year2013
Vol49
No9
Pages2477-2484
Publication size in sheets0.5
Keywords in EnglishLayer by layer; Redox active polymers; Surface mediate drug delivery; Microelectrode array; Dual response
ASJC Classification1605 Organic Chemistry; 2507 Polymers and Plastics; 3100 General Physics and Astronomy
DOIDOI:10.1016/j.eurpolymj.2013.01.029
URL http://www.sciencedirect.com/science/article/pii/S0014305713000670
Internal identifier14/DJ
Languageen angielski
File
1-s2.0-S0014305713000670-main.pdf 1.9 MB
Score (nominal)35
Score sourcejournalList
ScoreMinisterial score = 35.0, 31-01-2020, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 31-01-2020, ArticleFromJournal
Publication indicators Scopus Citations = 37; WoS Citations = 36; Scopus SNIP (Source Normalised Impact per Paper): 2013 = 1.66; WoS Impact Factor: 2013 = 3.242 (2) - 2013=3.245 (5)
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