The studies of cytotoxicity and antibacterial activity of composites with ZnO-doped bioglass

Ciołek Lidia , Monika Biernat , Zbigniew Jaegermann , Ewa Zaczyńska , Anna Czarny , Agnieszka Jastrzębska , Andrzej Olszyna

Abstract

The paper presents results of the studies on porous composites obtained using lyophilization method based on the solutions of the following polymers: chitosan, sodium alginate and polylactide, as well as ZnO‐doped CaO–SiO2–P2O5 bioglass. The researchers took the advantage of zinc ions demonstrating the bactericidal, immune‐stimulating, and tissue‐regenerating functions in the organism. The cytotoxicity of the composites was tested on L929 cells by means of the direct and the indirect contact method. The antibacterial properties were determined against the gram‐negative bacteria Pseudomonas aeruginosa and the gram‐positive bacteria Staphylococcus aureus at 24, 48 hours, and 7 days. The study demonstrated that changes due to cytotoxicity effect of the composites depend on the type of polymer and on the duration of contact with cells. The composite with polylactide was found to be the least toxic for L929 cells. ZnO added to the chemical composition of bioglass ensured bactericidal effects. The antibacterial properties of the composites depended on the ZnO content, bioglass grain size, polymer type, and composite microstructure. The composites presented in this paper are innovative as biomaterials for filling bone cavities because they can be a matrix for cells and have an antibacterial effect while supporting the regeneration of damaged tissue.
Author Ciołek Lidia
Ciołek Lidia,,
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, Monika Biernat - [Institute of Ceramics and Building Materials]
Monika Biernat,,
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, Zbigniew Jaegermann - [Institute of Ceramics and Building Materials]
Zbigniew Jaegermann,,
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, Ewa Zaczyńska - [Ludwik Hirszfeld Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences]
Ewa Zaczyńska,,
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, Anna Czarny - [Ludwik Hirszfeld Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences]
Anna Czarny,,
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, Agnieszka Jastrzębska (FMSE / DSMP)
Agnieszka Jastrzębska,,
- Division of Ceramic Materials and Polymers
, Andrzej Olszyna (FMSE / DSMP)
Andrzej Olszyna,,
- Division of Ceramic Materials and Polymers
Journal seriesInternational Journal of Applied Ceramic Technology, ISSN 1546-542X, (A 30 pkt)
Issue year2019
Vol16
No2
Pages541-551
Publication size in sheets0.5
Keywords in PolishAktywność antybakteryjna, bioszkło, kompozyt, cytotoksyczność
Keywords in EnglishAntibacterial activity, bioglass, composite, cytotoxicity
ASJC Classification2505 Materials Chemistry; 1406 Marketing; 3104 Condensed Matter Physics; 2503 Ceramics and Composites
DOIDOI:10.1111/ijac.13144
URL https://ceramics.onlinelibrary.wiley.com/doi/full/10.1111/ijac.13144
Languageen angielski
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The studies of cytotoxicity and antibacterial activity of composites with ZnO-doped bioglass.pdf 1.18 MB
Not used for evaluationyes
Score (nominal)0
ScoreMinisterial score = 30.0, 25-04-2019, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 11-03-2019, ArticleFromJournal
Publication indicators Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.674; WoS Impact Factor: 2017 = 1.165 (2) - 2017=1.175 (5)
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