Characteristics and deposition of aerosol drugs delivered to the nose

Tomasz Robert Sosnowski , Piotr Rapiejko

Abstract

In vitro measurements of intranasal deposition of aerosol droplets released from three different drug products are presented. The experiments were done in anatomical cast reproduced from CT scans of an adult human. Aerosols released from nasal atomizers were also characterized regarding droplet size distribution, jet geometry and velocity. The results indicate that all tested medicinal aerosols are characterized by similar droplet size but properties of the jets are different, and this is the main factor which influences the spatial distribution of drug deposition in the nasal cavity. In general, nasal aerosols are deposited proximally in the nasal cavity due to high momentum of the jet and constrictions present in internal geometry of the nose.
Author Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
, Piotr Rapiejko
Piotr Rapiejko,,
-
Pages1270-1272
Publication size in sheets0.3
Book The 22nd Polish Conference of Chemical and Process Engineering: Proceedings, 2016, Łódź, Faculty of Process and Environmental Engineering, ISBN 978-83-61997-75-7, 1584 p.
Proceedings OKIChiP 2016.pdf / No licence information (file archived - login or check accessibility on faculty)
Keywords in Englishnasal corticosteroids, aerosol, deposition, in vitro study
Languageen angielski
Score (nominal)0
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