3D Printing of Thermoresponsive Polyisocyanide (PIC) Hydrogels as Bioink and Fugitive Material for Tissue Engineering
Nehar Celikkin , Joan Simó Padial , Marco Costantini , Hans Hendrikse , Rebecca Cohn , Christopher Wilson , Alan Rowan , Wojciech Święszkowski
AbstractDespite the rapid and great developments in the field of 3D hydrogel printing, a major ongoing challenge is represented by the development of new processable materials that can be effectively used for bioink formulation. In this work, we present an approach to 3D deposit, a new class of fully-synthetic, biocompatible PolyIsoCyanide (PIC) hydrogels that exhibit a reverse gelation temperature close to physiological conditions (37 °C). Being fully-synthetic, PIC hydrogels are particularly attractive for tissue engineering, as their properties—such as hydrogel stiffness, polymer solubility, and gelation kinetics—can be precisely tailored according to process requirements. Here, for the first time, we demonstrate the feasibility of both 3D printing PIC hydrogels and of creating dual PIC-Gelatin MethAcrylate (GelMA) hydrogel systems. Furthermore, we propose the use of PIC as fugitive hydrogel to template structures within GelMA hydrogels. The presented approach represents a robust and valid alternative to other commercial thermosensitive systems—such as those based on Pluronic F127—for the fabrication of 3D hydrogels through additive manufacturing technologies to be used as advanced platforms in tissue engineering.
|Journal series||Polymers, ISSN 2073-4360, (A 40 pkt)|
|Publication size in sheets||0.3|
|Keywords in Polish||polimery termoreaktywne; Rusztowania 3D hydrożelowe; Bioprinting 3D; hydrożele poliizocyj ankowe (PIC); podwójny system hydrożelowy|
|Keywords in English||thermoresponsive polymers; 3D hydrogel scaffolds; 3D bioprinting; polyisocyanide (PIC) hydrogels; dual hydrogel system|
|Score|| = 40.0, 25-04-2019, ArticleFromJournal|
= 40.0, 11-03-2019, ArticleFromJournal
|Publication indicators||= 5; = 2; : 2017 = 1.213; : 2017 = 2.935 (2) - 2017=3.509 (5)|
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