3D Printing of Thermoresponsive Polyisocyanide (PIC) Hydrogels as Bioink and Fugitive Material for Tissue Engineering

Nehar Celikkin , Joan Simó Padial , Marco Costantini , Hans Hendrikse , Rebecca Cohn , Christopher Wilson , Alan Rowan , Wojciech Święszkowski


Despite the rapid and great developments in the field of 3D hydrogel printing, a major ongoing challenge is represented by the development of new processable materials that can be effectively used for bioink formulation. In this work, we present an approach to 3D deposit, a new class of fully-synthetic, biocompatible PolyIsoCyanide (PIC) hydrogels that exhibit a reverse gelation temperature close to physiological conditions (37 °C). Being fully-synthetic, PIC hydrogels are particularly attractive for tissue engineering, as their properties—such as hydrogel stiffness, polymer solubility, and gelation kinetics—can be precisely tailored according to process requirements. Here, for the first time, we demonstrate the feasibility of both 3D printing PIC hydrogels and of creating dual PIC-Gelatin MethAcrylate (GelMA) hydrogel systems. Furthermore, we propose the use of PIC as fugitive hydrogel to template structures within GelMA hydrogels. The presented approach represents a robust and valid alternative to other commercial thermosensitive systems—such as those based on Pluronic F127—for the fabrication of 3D hydrogels through additive manufacturing technologies to be used as advanced platforms in tissue engineering.
Author Nehar Celikkin (FMSE / DMD)
Nehar Celikkin,,
- Division of Materials Design
, Joan Simó Padial
Joan Simó Padial,,
, Marco Costantini - Università Campus Bio-Medico di Roma, Rome, Italy [Warsaw University of Technology (PW)]
Marco Costantini,,
- Politechnika Warszawska
, Hans Hendrikse - [Politechnika Warszawska]
Hans Hendrikse,,
, Rebecca Cohn (FMSE / DMD)
Rebecca Cohn,,
- Division of Materials Design
, Christopher Wilson - [Noviotech B.V.]
Christopher Wilson,,
, Alan Rowan - [Radboud University Nijmegen]
Alan Rowan,,
, Wojciech Święszkowski (FMSE / DMD)
Wojciech Święszkowski,,
- Division of Materials Design
Journal seriesPolymers, ISSN 2073-4360
Issue year2018
Publication size in sheets0.3
Keywords in Polishpolimery termoreaktywne; Rusztowania 3D hydrożelowe; Bioprinting 3D; hydrożele poliizocyj ankowe (PIC); podwójny system hydrożelowy
Keywords in Englishthermoresponsive polymers; 3D hydrogel scaffolds; 3D bioprinting; polyisocyanide (PIC) hydrogels; dual hydrogel system
ASJC Classification2507 Polymers and Plastics; 1600 General Chemistry
URL https://www.mdpi.com/2073-4360/10/5/555
Languageen angielski
polymers-10-00555 (2).pdf 3.19 MB
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 40.0, 10-06-2020, ArticleFromJournal
Publication indicators Scopus Citations = 10; WoS Citations = 2; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.057; WoS Impact Factor: 2017 = 2.935 (2) - 2017=3.509 (5)
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