How important are scaffolds and their surface properties in regenerative medicine
Joanna Idaszek , Ewa Kijeńska , M. Łojkowski , Wojciech Święszkowski
AbstractThe ability of cells to sense various cues present within their natural habitat gives a tremendous opportunity to steer their fate in vitro within artificial matrices (scaffolds). However, the variety of signals and their chemical and physical origin makes engineering of the scaffolds quite challenging and requires careful design in order to obtained the desired outcome. Herein, we discuss the effect of architecture and surface of scaffolds fabricated by means of additive manufacturing and electrospinning on cell retention, spreading, proliferation and differentiation. Additionally, we present some of the reported surface and bulk modifications of the scaffolds, which positively affected cell performance. Finally, in the last part we discuss application of multicellular spheroids as a useful tool to study cell performance within three-dimensional and porous structures. (C) 2016 Elsevier B.V. All rights reserved.
|Journal series||Applied Surface Science, ISSN 0169-4332|
|Publication size in sheets||0.6|
|Keywords in English||Scaffolds; Additive manufacturing; Electrospinning; Architecture; Surface properties; Tissue engineering|
|Score|| = 35.0, 28-11-2017, ArticleFromJournal|
= 35.0, 28-11-2017, ArticleFromJournal
|Publication indicators||: 2016 = 3.387 (2) - 2016=3.184 (5)|
|Citation count*||9 (2018-07-14)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.