How important are scaffolds and their surface properties in regenerative medicine

Joanna Idaszek , Ewa Kijeńska , M. Łojkowski , Wojciech Święszkowski

Abstract

The ability of cells to sense various cues present within their natural habitat gives a tremendous opportunity to steer their fate in vitro within artificial matrices (scaffolds). However, the variety of signals and their chemical and physical origin makes engineering of the scaffolds quite challenging and requires careful design in order to obtained the desired outcome. Herein, we discuss the effect of architecture and surface of scaffolds fabricated by means of additive manufacturing and electrospinning on cell retention, spreading, proliferation and differentiation. Additionally, we present some of the reported surface and bulk modifications of the scaffolds, which positively affected cell performance. Finally, in the last part we discuss application of multicellular spheroids as a useful tool to study cell performance within three-dimensional and porous structures. (C) 2016 Elsevier B.V. All rights reserved.
Author Joanna Idaszek WIM
Joanna Idaszek,,
- Faculty of Materials Science and Engineering
, Ewa Kijeńska WIM
Ewa Kijeńska,,
- Faculty of Materials Science and Engineering
, M. Łojkowski WIM
M. Łojkowski,,
- Faculty of Materials Science and Engineering
, Wojciech Święszkowski ZPM
Wojciech Święszkowski,,
- Division of Materials Design
Journal seriesApplied Surface Science, ISSN 0169-4332
Issue year2016
Vol388
Pages762-774
Publication size in sheets0.6
Keywords in EnglishScaffolds; Additive manufacturing; Electrospinning; Architecture; Surface properties; Tissue engineering
DOIDOI:10.1016/j.apsusc.2016.03.038
URL http://www.sciencedirect.com/science/article/pii/S0169433216304743
Languageen angielski
Score (nominal)35
ScoreMinisterial score = 35.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.387 (2) - 2016=3.184 (5)
Citation count*8 (2018-02-22)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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