Cascade impactor study of aerosolization process during passive dry powder inhaler performance under unsteady versus steady flow conditions
- Agata Dorosz,
- Paula Martínez Cánovas,
- Arkadiusz Moskal
The passive Dry Powder Inhalers (DPIs) rely on the human’sinspiratory airflow and negative pressure drop to create turbulent energy envi-ronment inside the inhaler. It induces the forces provided by theflowfield tofluidize and disperse the drug aggregates into respirable aerosol, exposed tofluidmotions. Hence, aerosolization, transport and deposition phenomena withrespect to unsteadyflow conditions constitute a subject of biomedical researchapplying methodology of chemical and process engineering. In vitro pharma-copoeia methods–inertial impaction sizing techniques–have been adopted toassess the aerodynamic performance of powder drug-device platforms. Thenecessity of investigating time-dependent breathing profiles during operation ofDPIs renders conventional testing insufficient. Recently, a method using cascadeimpactor, mixing inlet and breathing simulator has been developed. Thehypothesis of the study was proven to be true: the dynamics of theflow con-ditions influence the aerodynamic particle size distribution of a drug-passiveDPI platform. Research efforts focused on mimicking DPI drug delivery withtime-varyingflow profile may help to develop betterin vitro–in vivocorrelation(IVIVC) when linking the information gained from compendial testing toclinical efficacy. Further insight of quality parameters in time series is desired tobetter understand the dynamics of aerosolization process.
- Record ID
- Ochowiak Marek, Marek Ochowiak Woziwodzki Szymon, Szymon Woziwodzki Mitkowski Piotr Tomasz Piotr Tomasz Mitkowski [et al.] (eds.): Practical aspects of chemical engineering. Selected contributions from PAIC 2019, 2020, Cham (Switzerland), Springer, 499 p., ISBN 978-3-030-39866-8. DOI:10.1007/978-3-030-39867-5 Opening in a new tab
- DOI:10.1007/978-3-030-39867-5_6 Opening in a new tab
- (en) English
- File: 1
- Dorosz A. (i in.) - Cascade impactor study...pdf
- Score (nominal)
- Score source
- = 20.0, 11-05-2021, ChapterFromConference
- Additional fields
- Uwagi: This study was supported by the National Science Centre, Poland (projectno. 2017/25/N/ST8/00809).
- Uniform Resource Identifier
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