Tailored degradation of biocompatible poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/calcium silicate/poly(lactide-co-glycolide) ternary composites: An in vitro study

Joanna Idaszek , M. Zinn , M. Obarzanek-Fojt , V. Zell , Wojciech Święszkowski , A. Bruinink

Abstract

Biodegradable materials, which are currently available for bone tissue regeneration, still have limitations regarding their degradation rate, mechanical stability and/or biological response. Thus, a novel generation of materials for bioactive bone scaffolds is needed that triggers hydroxyapatite formation and can be tailored to suit application-specific requirements. In this study we developed ternary bioactive composite materials composed of poly(3-hydroxybutyrate-co-3-hydroxyvalerate), calcium silicate and poly(lactide-co-glycolide) (PHBV/CS/PLGA), which merged the good bioactivity CS/PHBV composite and the improved degradation velocity of PHBV/PLGA blend. Bioactive character of all composites was proven by formation of hydroxyapatite-like crystals after already one week of incubation in simulated body fluid. Addition of PLGA significantly increased initial ultimate tensile strength (UTS0) and Young's modulus of the ternary composites from 14.3 +/- 1.1 MPa (binary composite) to 22.3 +/- 2.6 MPa and 1.23 +/- 0.05 GPa up to 1.64 +/- 0.14 GPa, respectively. Furthermore the degradation rate (measured as a decrease of UTS during degradation) could be successfully tailored and was in range of -0.033 UTS0 to -0.118 UTS0 MPa/week. The bioacceptance of the materials was proven in vitro using 2-D (conventional setup) and 3-D (multicellular spheroids) human bone marrow stromal cell cultures. (C) 2013 Elsevier B.V. All rights reserved.
Author Joanna Idaszek (FMSE)
Joanna Idaszek,,
- Faculty of Materials Science and Engineering
, M. Zinn - [Empa - Swiss Federal Laboratories for Materials Science and Technology]
M. Zinn,,
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, M. Obarzanek-Fojt - [Empa - Swiss Federal Laboratories for Materials Science and Technology]
M. Obarzanek-Fojt,,
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, V. Zell - [Empa - Swiss Federal Laboratories for Materials Science and Technology]
V. Zell,,
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, Wojciech Święszkowski (FMSE / DMD)
Wojciech Święszkowski,,
- Division of Materials Design
, A. Bruinink - [Empa - Swiss Federal Laboratories for Materials Science and Technology]
A. Bruinink,,
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Journal seriesMaterials Science & Engineering C-Materials for Biological Applications, ISSN 0928-4931
Issue year2013
Vol33
No7
Pages4352-4360
Publication size in sheets0.5
Keywords in EnglishComposite; Biodegradation; Mechanical properties; Biocompatibility; Mesenchymal stem cell; Polyhydroxyalkanoate
ASJC Classification2210 Mechanical Engineering; 2211 Mechanics of Materials; 3104 Condensed Matter Physics; 2500 General Materials Science
DOIDOI:10.1016/j.msec.2013.06.025
URL http://www.sciencedirect.com/science/article/pii/S0928493113003846
Languageen angielski
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 25.0, 10-06-2020, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 10-06-2020, ArticleFromJournal
Publication indicators Scopus Citations = 13; WoS Citations = 11; GS Citations = 15.0; Scopus SNIP (Source Normalised Impact per Paper): 2013 = 1.369; WoS Impact Factor: 2013 = 2.736 (2) - 2013=3.076 (5)
Citation count*15 (2020-09-01)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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