The role of apelin in central cardiovascular regulation in rats with post-infarct heart failure maintained on a normal fat or high fat diet
K. Czarzasta , A. Cudnoch-Jedrzejewska , E. Szczepańska-Sadowska , Łukasz Fus , Liana Puchalska , Agata Gondek , Jakub Dobruch , Ryszard Gomółka , Robert Wrzesień , Tymoteusz Zera , Barbara Górnicka , Marek Kuch
AbstractBased on the available literature, it can be assumed that in cases of post-infarct heart failure (HF) and obesity, a significant change in the central regulation of the cardiovascular system takes place with, among others, the involvement of the apelinergic system. The main objective of the present study was to clarify the role of apelin-13 in the central regulation of the cardiovascular system in Sprague Dawley rats with HF or sham operated (SO) and fed on a normal fat (NFD) or a high fat diet (HFD). The study was divided into two parts: Part I, hemodynamic studies; and Part II, biochemical and molecular studies. The animals were subjected to the following research procedures. Part I and II: feeding NFD or HFD; experimental induction of HF or SO; Part I: intracerebroventricular (ICV) infusion of the examined substances, monitoring of mean arterial blood pressure (MABP) and heart rate (HR); Part II: venous blood and tissue samples collected. ICV infusion of apelin-13 caused significantly higher changes in ΔMABP in the SO NFD group. No changes were noted in ΔHR in any of the studied groups. Apelin and apelin receptor (APJ) mRNA expression in the brain and adipose tissues was higher in the HF rats. HFD causes significant increase in expression of apelin and APJ mRNA in the left ventricle. In conclusion, HF and HFD appear to play an important role in modifying the activity of the central apelinergic system and significant changes in mRNA expression of apelin and APJ receptor.
|Journal series||Clinical and Experimental Pharmacology and Physiology, ISSN 1440-1681 [0305-1870]|
|Publication size in sheets||0.55|
|Keywords in English||apelin; APJ receptor; blood pressure; high fat diet; post-infarct heart failure|
|project||Research on measurement, circuit and signal theory and electronic circuits and systems. Project leader: Starecki Tomasz,
, Phone: +48 22 825 37 09; 22 234 7744; +48 22 234 3657, start date 12-05-2016, end date 31-12-2017, ISE/2016/DS, Completed
|Score|| = 20.0, 27-03-2017, ArticleFromJournal|
= 25.0, 27-03-2017, ArticleFromJournal
|Publication indicators||: 2016 = 2.01 (2) - 2016=2.299 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.