Development of an SBU-Based Mechanochemical Approach for Drug-Loaded MOFs
Authors:
- Jan Nawrocki,
- Daniel Prochowicz,
- A. Wiśniewski,
- Iwona Justyniak,
- Piotr Goś,
- Janusz Lewiński
Abstract
Metal–organic frameworks (MOFs) have attracted a great deal of attention in the areas of biomedicine due to their versatile porous structures and are potentially ideal vehicles for loading bioactive molecules and controlling the release of small molecules. Current approaches for encapsulation of drug molecules in MOFs are usually based on multistep wet processes. We report here a novel simple and rapid solid-state process that combines the mechanosynthesis of HKUST-1 and the encapsulation of ibuprofen (IBU-H), as a model drug molecule, in a one-pot reaction involving a pre-assembled [Cu2(IBU)4]·2DMF cluster. The ibuprofen-loaded MOF composite (with 58.5 wt.-% loading capacity) was also studied as a drug delivery carrier system in phosphate buffered saline (PBS) solution at 37 °C.
- Record ID
- WUTe5dc8aadb9ec4e808a2217165ccad2b8
- Author
- Journal series
- European Journal of Inorganic Chemistry, ISSN 1434-1948, e-ISSN 1099-0682, [0009-2940]
- Issue year
- 2020
- Vol
- 2020
- Pages
- 796-800
- Publication size in sheets
- 0.50
- ASJC Classification
- DOI
- DOI:10.1002/ejic.201901194 Opening in a new tab
- URL
- https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejic.201901194 Opening in a new tab
- Language
- (en) English
- File
-
- File: 1
- ejic.201901194.pdf
-
- Score (nominal)
- 70
- Score source
- journalList
- Score
- = 70.0, 12-05-2022, ArticleFromJournal
- Publication indicators
- = 7; = 2; : 2018 = 0.601; : 2020 (2 years) = 2.524 - 2020 (5 years) =2.431
Share
- Uniform Resource Identifier
- https://repo.pw.edu.pl/info/article/WUTe5dc8aadb9ec4e808a2217165ccad2b8/
- URN
urn:pw-repo:WUTe5dc8aadb9ec4e808a2217165ccad2b8
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.