Development of an SBU-Based Mechanochemical Approach for Drug-Loaded MOFs

Jan Nawrocki , Daniel Prochowicz , A. Wiśniewski , Iwona Justyniak , Piotr Goś , Janusz Lewiński

Abstract

Metal–organic frameworks (MOFs) have attracted a great deal of attention in the areas of biomedicine due to their versatile porous structures and are potentially ideal vehicles for loading bioactive molecules and controlling the release of small molecules. Current approaches for encapsulation of drug molecules in MOFs are usually based on multistep wet processes. We report here a novel simple and rapid solid-state process that combines the mechanosynthesis of HKUST-1 and the encapsulation of ibuprofen (IBU-H), as a model drug molecule, in a one-pot reaction involving a pre-assembled [Cu2(IBU)4]·2DMF cluster. The ibuprofen-loaded MOF composite (with 58.5 wt.-% loading capacity) was also studied as a drug delivery carrier system in phosphate buffered saline (PBS) solution at 37 °C.

Author Jan Nawrocki - [Polish Academy of Sciences]
Jan Nawrocki,,
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, Daniel Prochowicz (FC / DCOC)
Daniel Prochowicz,,
- Department Of Catalysis And Organometallic Chemistry
, A. Wiśniewski (WUT)
A. Wiśniewski,,
- Warsaw University of Technology
, Iwona Justyniak (FC)
Iwona Justyniak,,
- Faculty of Chemistry
, Piotr Goś - [Graduate and Postgraduate School]
Piotr Goś,,
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, Janusz Lewiński (FC / DCOC)
Janusz Lewiński,,
- Department Of Catalysis And Organometallic Chemistry
Journal seriesEuropean Journal of Inorganic Chemistry, [Chemische Berichte], ISSN 1434-1948, e-ISSN 1099-0682, [0009-2940]
Issue year2020
Vol2020
Pages796-800
Publication size in sheets0.5
ASJC Classification1604 Inorganic Chemistry
DOIDOI:10.1002/ejic.201901194
URL https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejic.201901194
Languageen angielski
File
ejic.201901194.pdf 869.23 KB
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 27-07-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.601; WoS Impact Factor: 2018 = 2.578 (2) - 2018=2.301 (5)
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