Redox Activity of Copper(II) Complexes with NSFRY Pentapeptide and Its Analogues

Magdalena Wiloch , Urszula Wawrzyniak , Iwona Ufnalska , Grzegorz Piotrowski , Arkadiusz Bonna , Wojciech Wróblewski

Abstract

The influence of cation-π interactions on the electrochemical properties of copper(II) complexes with synthesized pentapeptide C-terminal fragment of Atrial Natriuretic Factor (ANF) hormone was studied in this work. Molecular modeling performed for Cu(II)-NSFRY-NH2 complex indicated that the cation-π interactions between Tyr and Cu(II), and also between Phe-Arg led to specific conformation defined as peptide box, in which the metal cation is isolated from the solvent by peptide ligand. Voltammetry experiments enabled to compare the redox properties and stability of copper(II) complexes with NSFRY-NH2 and its analogues (namely: NSFRA-NH2, NSFRF-NH2, NSAAY-NH2, NSAAA-NH2, AAAAA-NH2) as well as to evaluate the contribution of individual amino acid residues to these properties. The obtained results led to the conclusion, that cation-π interactions play a crucial role in the effective stabilization of copper(II) complexes with the fragments of ANF peptide hormone and therefore could control the redox processes in other metalloproteins.
Author Magdalena Wiloch ZMB
Magdalena Wiloch,,
- Department Of Microbioanalytics
, Urszula Wawrzyniak ZMB
Urszula Wawrzyniak,,
- Department Of Microbioanalytics
, Iwona Ufnalska ZMB
Iwona Ufnalska,,
- Department Of Microbioanalytics
, Grzegorz Piotrowski
Grzegorz Piotrowski,,
-
, Arkadiusz Bonna
Arkadiusz Bonna,,
-
, Wojciech Wróblewski ZMB
Wojciech Wróblewski,,
- Department Of Microbioanalytics
Journal seriesPlos One, ISSN 1932-6203
Issue year2016
Vol11
No8
Pages1-13
Publication size in sheets0.6
DOIDOI:10.1371/journal.pone.0160256
URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160256
Languageen angielski
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Redox Activity of Copper(II) Complexes with.pdf 1.22 MB
Score (nominal)40
ScoreMinisterial score = 35.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.806 (2) - 2016=3.394 (5)
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