Piperazine derivatives of boronic acids - potential bifunctional biologically active compounds

Agnieszka Adamczyk-Woźniak , Karolina Czerwińska , Izabela Madura , Alicja Matuszewska , Andrzej Sporzyński , Anna Żubrowska

Abstract

The combination of a piperazine and boronic groups within one molecule can result in a totally novel biological activity. A series of benzyl piperazine derivatives of boronic acids have been obtained by the facile and effective method based on the amination-reduction reaction of 2-formylphenylboronic acid with N-substituted piperazines. The molecular and crystal structures of six novel derivatives have been investigated, along with Hirshfeld surface analysis and hydrogen bond energy estimation. The studied compounds display several structural features that make them promising candidates as biologically active compounds.
Author Agnieszka Adamczyk-Woźniak (FC / DPC)
Agnieszka Adamczyk-Woźniak,,
- Department Of Physical Chemistry
, Karolina Czerwińska (FC / CICSST)
Karolina Czerwińska,,
- Chair Of Inorganic Chemistry And Solid State Technology
, Izabela Madura (FC / CICSST)
Izabela Madura,,
- Chair Of Inorganic Chemistry And Solid State Technology
, Alicja Matuszewska (FC / DPC)
Alicja Matuszewska,,
- Department Of Physical Chemistry
, Andrzej Sporzyński (FC / DPC)
Andrzej Sporzyński,,
- Department Of Physical Chemistry
, Anna Żubrowska (FC / DPC)
Anna Żubrowska,,
- Department Of Physical Chemistry
Journal seriesNew Journal of Chemistry, ISSN 1144-0546, (A 30 pkt)
Issue year2015
Vol39
Pages4308-4315
Publication size in sheets0.5
DOIDOI:10.1039/C5NJ00084J
URL http://pubs.rsc.org/en/Content/ArticleLanding/2015/NJ/c5nj00084j#!divAbstract
Languageen angielski
File
c5nj00084j.pdf 2.06 MB
Score (nominal)30
ScoreMinisterial score = 30.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2015 = 3.277 (2) - 2015=3.247 (5)
Citation count*3 (2016-06-01)
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