Lab-on-a-chip systems for photodynamic therapy investigations
Michał Chudy , Katarzyna Tokarska , Elżbieta Jastrzębska , Magdalena Bułka , Sławomir Drozdek , Łukasz Lamch , Kazimiera Anna Wilk , Zbigniew Brzózka
AbstractIn recent years photodynamic therapy (PDT) has received widespread attention in cancer treatment due to its smaller surgical trauma, better selectivity towards tumor cells, reduced side effects and possibility of repeatable treatment. Since cancer is the second cause of death worldwide, scientists constantly seek for new potential therapeutic agents including nanotechnology-based photosensitizers used in PDT. The new-designed nanostructures must be carefully studied and well characterized what require analytically useful and powerful tools that enable real progress in nanoscience development. This review describes the current status of PDT investigations using microfluidic Lab-on-a-Chip systems, including recent developments of nanoparticle-based PDT agents, their combinations with different drugs, designs and examples of in vitro applications. This review mainly lays emphasis on biological evaluation of FDA approved photosensitizing agents as well as newly designed nanophotosensitizers. It also highlights the analytical performances of various microfluidic Lab-on-a-chip systems for PDT efficacy analysis on 3D culture and discusses microsystems designs in detail.
|Journal series||Biosensors & Bioelectronics, ISSN 0956-5663, (A 40 pkt)|
|Publication size in sheets||0.7|
|Keywords in English||Lab-on-a-chipCancerPhotodynamic therapyCombination therapyNanotechnology|
|ASJC Classification||; ; ; ;|
|Score||= 40.0, 28-05-2019, ArticleFromJournal|
|Publication indicators||= 8; = 9; : 2016 = 1.633; : 2017 = 8.173 (2) - 2017=7.291 (5)|
|Citation count*||8 (2019-07-23)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.