Lab-on-a-chip systems for photodynamic therapy investigations

Michał Chudy , Katarzyna Tokarska , Elżbieta Jastrzębska , Magdalena Bułka , Sławomir Drozdek , Łukasz Lamch , Kazimiera Anna Wilk , Zbigniew Brzózka

Abstract

In recent years photodynamic therapy (PDT) has received widespread attention in cancer treatment due to its smaller surgical trauma, better selectivity towards tumor cells, reduced side effects and possibility of repeatable treatment. Since cancer is the second cause of death worldwide, scientists constantly seek for new potential therapeutic agents including nanotechnology-based photosensitizers used in PDT. The new-designed nanostructures must be carefully studied and well characterized what require analytically useful and powerful tools that enable real progress in nanoscience development. This review describes the current status of PDT investigations using microfluidic Lab-on-a-Chip systems, including recent developments of nanoparticle-based PDT agents, their combinations with different drugs, designs and examples of in vitro applications. This review mainly lays emphasis on biological evaluation of FDA approved photosensitizing agents as well as newly designed nanophotosensitizers. It also highlights the analytical performances of various microfluidic Lab-on-a-chip systems for PDT efficacy analysis on 3D culture and discusses microsystems designs in detail.
Author Michał Chudy (FC / IBC / DM)
Michał Chudy,,
- Department Of Microbioanalytics
, Katarzyna Tokarska (FC / IBC / DM)
Katarzyna Tokarska,,
- Department Of Microbioanalytics
, Elżbieta Jastrzębska (FC / IBC / DM)
Elżbieta Jastrzębska,,
- Department Of Microbioanalytics
, Magdalena Bułka (FC / IBC / DM)
Magdalena Bułka,,
- Department Of Microbioanalytics
, Sławomir Drozdek - [Wrocław University of Science and Technology]
Sławomir Drozdek,,
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, Łukasz Lamch - [Wrocław University of Science and Technology]
Łukasz Lamch,,
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, Kazimiera Anna Wilk - [Wrocław University of Science and Technology]
Kazimiera Anna Wilk,,
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, Zbigniew Brzózka (FC / IBC / DM)
Zbigniew Brzózka,,
- Department Of Microbioanalytics
Journal seriesBiosensors & Bioelectronics, ISSN 0956-5663, (A 40 pkt)
Issue year2018
Vol101
Pages37-51
Publication size in sheets0.7
Keywords in EnglishLab-on-a-chipCancerPhotodynamic therapyCombination therapyNanotechnology
ASJC Classification1603 Electrochemistry; 2204 Biomedical Engineering; 2700 General Medicine; 1304 Biophysics; 1305 Biotechnology
DOIDOI:10.1016/j.bios.2017.10.013
URL https://www.sciencedirect.com/science/article/pii/S0956566317306723
Languageen angielski
File
wdpb_publikacje_pliki_plik_publikacja_3334_org.pdf 1.46 MB
Score (nominal)40
ScoreMinisterial score = 40.0, 28-05-2019, ArticleFromJournal
Publication indicators WoS Citations = 8; Scopus Citations = 9; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.633; WoS Impact Factor: 2017 = 8.173 (2) - 2017=7.291 (5)
Citation count*8 (2019-07-23)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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