Increased plasma tissue inhibitors of metalloproteinase concentrations as negative predictors associated with deterioration of kidney allograft function upon long-term observation

O. Mazanowska , Dorota Kamińska , M. Serwin-Krajewska , Mariusz Banasik , M. Zabińska , K. Kościelska-Kasprzak , Przemysław Biecek , P. Chudoba , D. Patrzałek , M. Boratyńska , M. Klinger

Abstract

Chronic allograft injury (CAI) is the most frequent cause of progressive kidney allograft impairment and eventual loss, which is due to interstitial fibrosis and tubular atrophy (IF/TA). Mechanisms of CAI are not fully understood. Chemokines, cytokines, metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs) play roles in fibrosis development. The aims of this study were to evaluate plasma and urine TIMPs (TIMP-1 and TIMP-2), MMPs (MMP-2 and MMP-9), proinflammatory interleukin-6 (IL-6), chemokine (C-C motif) ligand 2 (CCL2 chemokines previously known as monocyte chemoattractant protein-1 [MCP-1]) among 150 recipients beyond 1 year post-renal transplantations and to explore the usefulness of these potential biomarkers of ongoing allograft injury. Renal transplant recipients compared with healthy volunteers (control group) showed significantly increased plasma and urine IL-6, MMP-9, TIMP-1, and TIMP-2, as well as lower plasma MMP-2 and urine CCL2 concentrations. Compared with recipients showing good function those with impairments displayed higher plasma TIMP-1 (P <.001) and TIMP-2 (P =.003) concentrations. The recipient estimated glomerular filtration rate (eGFR) values negatively correlated with plasma TIMP-1 and TIMP-2 levels (r = -0.43; P <.0001 and rs = -0.42; P <.0001, respectively) and with urine IL-6 excretion (rs = -0.33; P <.0001). Multivariate and receiver operating characteristic (ROC) analyses showed TIMP-1 plasma level assessments to be useful estimates of allograft injury. © 2013 Elsevier Inc. All rights reserved.

Author O. Mazanowska - [Wroclaw Medical University]
O. Mazanowska,,
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, Dorota Kamińska (FCPE)
Dorota Kamińska,,
- Faculty of Chemical and Process Engineering
, M. Serwin-Krajewska
M. Serwin-Krajewska,,
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, Mariusz Banasik
Mariusz Banasik,,
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, M. Zabińska - [Wroclaw Medical University]
M. Zabińska,,
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, K. Kościelska-Kasprzak - [Wroclaw Medical University]
K. Kościelska-Kasprzak,,
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, Przemysław Biecek (FMIS / DCSDCAM)
Przemysław Biecek,,
- Department of CAD/CAM Systems Design and Computer-Aided Medicine
, P. Chudoba - [Wroclaw Medical University]
P. Chudoba,,
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, D. Patrzałek - [Wroclaw Medical University]
D. Patrzałek,,
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, M. Boratyńska - [Wroclaw Medical University]
M. Boratyńska,,
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et al.`
Journal seriesTransplantation Proceedings, ISSN 0041-1345
Issue year2013
Vol45
Pages1458-1461
ASJC Classification2747 Transplantation; 2746 Surgery
DOIDOI:10.1016/j.transproceed.2013.02.109
Languageen angielski
Score (nominal)15
Score sourcejournalList
ScoreMinisterial score = 15.0, 03-02-2020, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 03-02-2020, ArticleFromJournal
Publication indicators Scopus Citations = 4; WoS Citations = 3; Scopus SNIP (Source Normalised Impact per Paper): 2013 = 0.565; WoS Impact Factor: 2013 = 0.984 (2) - 2013=1.02 (5)
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