Impact of physicochemical properties of nasal spray products on drug deposition and transport in the pediatric nasal cavity model

Tomasz Robert Sosnowski , Piotr Rapiejko , Jarosław Sova , Katarzyna Ewa Dobrowolska

Abstract

The study is focused on the analysis of physicochemical properties of selected nasal sprays of mometasone furoate, and the influence of these properties on aerosol quality and penetration in the pediatric nose. After the determination of drugs surface tension and viscosity, spray geometry and size distribution of aerosol droplets, the topical delivery of each drug to different parts of the pediatric model of the nose with the flexible vestibule was evaluated by colorimetric visualization. All tested drugs are pseudo-plastic liquids, showing some differences in flow consistency constant k (range 714–1422) and flow behavior index n (range 0.16–0.31). At no-flow conditions, all sprays are deposited mainly in the anterior of the nasal cavity and the septum (2–3 cm from the nostril), as a result of inertial impaction of large droplets. The deposition range is slightly influenced by the geometry of the aerosol cloud, which, in turn, depends both on drug properties and the type of the spraying nozzle. Deposition experiments accompanied by the airflow show an enhancement of drug transport to deeper parts of the nasal cavity (up 4–6 cm from the vestibule), and this effect can be attributed to the secondary effects of spreading of the deposited liquid layer along the narrow air passages in the nose. Plume geometry, dose volume and rheological properties of the drug were shown to be important factors in the spray penetration pattern in the pediatric nose. The deepest delivery can be expected for drugs of low viscosity and short aerosol plumes.
Author Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
, Piotr Rapiejko
Piotr Rapiejko,,
-
, Jarosław Sova
Jarosław Sova,,
-
, Katarzyna Ewa Dobrowolska (FCPE / CIPE)
Katarzyna Ewa Dobrowolska,,
- Chair of Integrated Process Engineering
Journal seriesInternational Journal of Pharmaceutics, ISSN 0378-5173, e-ISSN 1873-3476
Issue year2020
Vol574
Pages1-10
Publication size in sheets0.5
Article number118911
Keywords in Englishnasal sprays, mometasone, drug penetration, deposition, in vitro model
ASJC Classification3003 Pharmaceutical Science
DOIDOI:10.1016/j.ijpharm.2019.118911
URL https://reader.elsevier.com/reader/sd/pii/S0378517319309561?token=1BD87CA77962DBDB6F3E60FBD0C40E16B2FDC797D86332CDD8B0DB0CD362F8CD81367E4DC3E404E4A9B12E721E503E6A
Languageen angielski
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Sosnowski T.R. (i in.) - Impact of physicochemical...pdf 7.06 MB
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 09-09-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus Citations = 1; GS Citations = 4.0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.23; WoS Impact Factor: 2018 = 4.213 (2) - 2018=4.417 (5)
Citation count*4 (2020-08-16)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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