Critical closing pressure during experimental intracranial hypertension: comparison of three calculation methods

Katarzyna Kaczmarska , Agnieszka Uryga , Michał M. Placek , Leanne Calviello , Magdalena Kasprowicz , Georgios V Varsos , Z Czosnyka , Ewa Koźniewska , T. Sierzputowski , Waldemar Koszewski , Marek Czosnyka

Abstract

Objectives: The critical closing pressure (CrCP) defines arterial blood pressure below which cerebral arteries collapse. It represents a clinically relevant parameter for the estimation of cerebrovascular tone. Although there are few methods to assess CrCP, there is no consensus which of them estimates this parameter most accurately. The aim of present retrospective, experimental study was to compare three methods of CrCP estimation: conventional Aaslid’s formula and methods based on the cerebrovascular impedance: the established continuous flow forward (CFF) and a new pulsatile flow forward (PFF) model. Methods: The effects of the following physiological manoeuvres on the CrCP were studied in New Zealand white rabbits: lumbar infusion of Hartmann’s solution to induce mild intracranial hypertension, sympathetic blockade to induce arterial hypotension, and modulation of respiratory tidal volume to induce hypocapnia or hypercapnia. Results: During intracranial hypertension, all CrCP estimates were significantly higher than at baseline, decreased with decreasing ABP and increased with gradual hypocapnia. During hypercapnia, all CrCP estimates were significantly decreased but only in the case of CrCPA the negative, non-physiological values were observed (16% of the cases). The Bland–Altman analysis revealed that a good agreement between each impedance method and Aaslid’s method deteriorated significantly in the low range of the average numerical value of the estimates. Discussion: Our results confirm the limited usage of Aaslid’s formula for the calculation of CrCP. Although both impedance methods seem to be equivalent, the fact that PFF model better describes cerebrovascular hemodynamic allows the recommendation of this model for the calculation of CrCP.

Author Katarzyna Kaczmarska (FEIT / PE)
Katarzyna Kaczmarska,,
- The Institute of Electronic Systems
, Agnieszka Uryga
Agnieszka Uryga,,
-
, Michał M. Placek - [Wrocław University of Science and Technology]
Michał M. Placek,,
-
-
, Leanne Calviello - [University of Cambridge]
Leanne Calviello,,
-
-
, Magdalena Kasprowicz
Magdalena Kasprowicz,,
-
, Georgios V Varsos
Georgios V Varsos,,
-
, Z Czosnyka
Z Czosnyka,,
-
, Ewa Koźniewska - [Miroslaw Mossakowski Medical Research Center of the Polish Academy of Sciences]
Ewa Koźniewska,,
-
-
, T. Sierzputowski
T. Sierzputowski,,
-
, Waldemar Koszewski - [Medical University of Warsaw]
Waldemar Koszewski,,
-
-
et al.`
Journal seriesNeurological Research, ISSN 0161-6412, e-ISSN 1743-1328
Issue year2020
Vol42
No5
Pages387-397
Publication size in sheets0.5
Keywords in English Intracranial pressure, critical closing pressure, infusion test, cerebral arterial blood volume
ASJC Classification2700 General Medicine; 2728 Clinical Neurology; 2808 Neurology
DOIDOI:10.1080/01616412.2020.1733323
URL https://pubmed.ncbi.nlm.nih.gov/32167031/
Languageen angielski
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 17-07-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.591; WoS Impact Factor: 2018 = 1.983 (2) - 2018=1.773 (5)
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