Surface Modification of 3D Printed Polycaprolactone Constructs via a Solvent Treatment: Impact on Physical and Osteogenic Properties

Alicja Kosik-Kozioł , Elizabeth Graham , Jakub Jaroszewicz , Adrian Chlanda , P. T. Sudheesh Kumar , Saso Ivanovski , Wojciech Święszkowski , Cedryck Vaquette

Abstract

One promising strategy to reconstruct bone defects relies on 3D printed porous structures. In spite of several studies having been carried out to fabricate controlled, interconnected porous constructs, the control over surface features at, or below, the microscopic scale remains elusive for 3D polymeric scaffolds. In this study, we developed and refined a methodology which can be applied to homogeneously and reproducibly modify the surface of polymeric 3D printed scaffolds. We have demonstrated that the combination of a polymer solvent and the utilization of ultrasound was essential for achieving appropriate surface modification without damaging the structural integrity of the construct. The modification created on the scaffold profoundly affected the macroscopic and microscopic properties of the scaffold with an increased roughness, greater surface area, and reduced hydrophobicity. Furthermore, to assess the performance of such materials in bone tissue engineering, human mesenchymal stem cells (hMSC) were cultured in vitro on the scaffolds for up to 7 days. Our results demonstrate a stronger commitment toward early osteogenic differentiation of hMSC. Finally, we demonstrated that the increased in the specific surface area of the scaffold did not necessarily correlate with improved adsorption of protein and that other factors, such as surface chemistry and hydrophilicity, may also play a major role.
Author Alicja Kosik-Kozioł (FMSE / DMD)
Alicja Kosik-Kozioł,,
- Division of Materials Design
, Elizabeth Graham - [Queensland University of Technology QUT]
Elizabeth Graham,,
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, Jakub Jaroszewicz (FMSE / DMD)
Jakub Jaroszewicz,,
- Division of Materials Design
, Adrian Chlanda (FMSE / DMD)
Adrian Chlanda,,
- Division of Materials Design
, P. T. Sudheesh Kumar - [Griffith University]
P. T. Sudheesh Kumar,,
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, Saso Ivanovski - [Griffith University]
Saso Ivanovski,,
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, Wojciech Święszkowski (FMSE / DMD)
Wojciech Święszkowski,,
- Division of Materials Design
, Cedryck Vaquette - [Queensland University of Technology QUT]
Cedryck Vaquette,,
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Journal seriesACS Biomaterials Science & Engineering, ISSN 2373-9878, (0 pkt)
Issue year2019
Vol5
No1
Pages318-328
Publication size in sheets0.5
Keywords in EnglishBMP-2 adsorption; polycaprolactone; solvent treatment; surface modification
ASJC Classification2204 Biomedical Engineering; 2502 Biomaterials
DOIDOI:10.1021/acsbiomaterials.8b01018
URL https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.8b01018
Languageen angielski
File
10.1021acsbiomaterials.8b01018 .pdf 927.64 KB
Score (nominal)5
ScoreMinisterial score = 0.0, 06-02-2019, ArticleFromJournal
Ministerial score (2013-2016) = 5.0, 06-02-2019, ArticleFromJournal - czasopismo zagraniczne spoza list
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.71; WoS Impact Factor: 2017 = 4.432 (2) - 2017=4.435 (5); Scopus Citations = 0; WoS Citations = 0
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