Iron in typical and atypical parkinsonism – Mössbauer spectroscopy and MRI studies

R Kuliński , E.R.b Bauminger , A. Friedman , Przemysław Duda , Jolanta Gałązka-Friedman

Abstract

Iron may play important role in neurodegeneration. The results of comparative studies of human brain areas (control and pathological) performed by Mössbauer spectroscopy (MS) and magnetic resonance imaging (MRI) techniques are presented. Mössbauer spectroscopy demonstrated a higher concentration of iron in atypical parkinsonism (progressive supranuclear palsy PSP) in the brain areas Substantia Nigra (SN) and Globus Pallidus (GP) involved in this pathological process, compared to control, while the concentration of iron in pathological tissues in typical parkinsonism (Parkinson’s disease - PD) did not differ from that in control. These results were compared with the changes in 1/T1 and 1/T2 (T1 and T2 being the relaxation times determined by MRI). A good linear correlation curve was found between the concentration of iron as determined by MS in different areas of control human brains and between 1/T1 and 1/T2. Whereas the finding in PSP-GP (the brain area involved in PSP) also fitted to such a correlation, this was not so for the correlation between pathological SN – the brain area involved in both diseases – and 1/T2, indicating a dependence of T2 on other factors than just the concentration of iron. © 2016, The Author(s).
Author R Kuliński - [Bródno Regional Hospital]
R Kuliński,,
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, E.R.b Bauminger - [Hebrew University of Jerusalem]
E.R.b Bauminger,,
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, A. Friedman - [Medical University of Warsaw]
A. Friedman,,
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, Przemysław Duda (FP / NPD)
Przemysław Duda,,
- Nuclear Physics Division
, Jolanta Gałązka-Friedman (FP / SRD)
Jolanta Gałązka-Friedman,,
- Structural Research Division
Journal seriesHyperfine Interactions, ISSN 0304-3843, [1572-9540]
Issue year2016
Vol237
No1
Pages1-8
Publication size in sheets0.5
Keywords in EnglishBrain iron; MRI relaxation times; Mössbauer spectroscopy; Parkinsonism
ASJC Classification1606 Physical and Theoretical Chemistry; 3104 Condensed Matter Physics; 3106 Nuclear and High Energy Physics; 3107 Atomic and Molecular Physics, and Optics
DOIDOI:10.1007/s10751-016-1234-4
URL http://www.scopus.com/inward/record.url?eid=2-s2.0-84958769348&partnerID=40&md5=8ecb739ce39f1eb617c085943d125041
Languageen angielski
File
friedman2016.pdf 1.27 MB
Score (nominal)5
Score sourcejournalList
ScoreMinisterial score = 0.0, 31-01-2020, ArticleFromJournal
Ministerial score (2013-2016) = 5.0, 31-01-2020, ArticleFromJournal
Publication indicators Scopus Citations = 3; WoS Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.49; WoS Impact Factor: 2007 = 0.209 (2) - 2007=0.313 (5)
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