Selected engineering and physicochemical aspects of systemic drug delivery by inhalation

Tomasz Robert Sosnowski

Abstract

Inhalation of aerosolized pharmaceuticals is a non-invasive and convenient method of drug delivery typically used for local treatment of lung diseases. Large absorption area of the pulmonary region opens up the possibility of fast and effective transfer of inhaled medicines to the circulation in order to obtain systemic effects. This review is devoted to selected albeit essential challenges of targeting aerosolized drugs to the blood via the pulmonary part of the respiratory system. The special attention is given to some physicochemical aspects of drug formulation which are essential for overcoming the air-blood barrier present in the lungs. It is deemed that a careful analysis of multifarious physical and engineering problems, related to aerosol fate in the lungs, is indispensable for a better design of inhalation delivery systems for systemic drugs.
Author Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
Journal seriesCurrent Pharmaceutical Design, ISSN 1381-6128, (A 35 pkt)
Issue year2016
Vol22
No17
Pages2453-2462
Publication size in sheets0.5
Keywords in Englishaerosol, inhalation, deposition, particles, air-blood barrier, surfactant
ASJC Classification3002 Drug Discovery; 3004 Pharmacology
DOIDOI:10.2174/1381612822666160128145644
URL http://benthamscience.com/journals/current-pharmaceutical-design/volume/22/issue/17/page/2453/
Languageen angielski
Score (nominal)35
ScoreMinisterial score = 30.0, 05-09-2019, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 05-09-2019, ArticleFromJournal
Publication indicators WoS Citations = 7; Scopus Citations = 6; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.817; WoS Impact Factor: 2016 = 2.611 (2) - 2016=3.0 (5)
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