The influence of fluorine position on the properties of fluorobenzoxaboroles
Agnieszka Adamczyk-Woźniak , Małgorzata K. Cabaj , Paulina M. Dominiak , Patrycja Gajowiec , Błażej Gierczyk , Jacek Lipok , Łukasz Popenda , Grzegorz Schroeder , Ewelina Tomecka , Piotr Urbański , Dorota Wieczorek , Andrzej Sporzyński
Abstract5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pKa and multinuclear NMR characterization. The molecular and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690.
|Journal series||Bioorganic Chemistry, ISSN 0045-2068, (A 25 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Benzoxaboroles; Tavaborole; Antifungal activity; Crystal structure|
|ASJC Classification||; ; ;|
|Score|| = 20.0, 21-03-2019, ArticleFromJournal|
= 25.0, 21-03-2019, ArticleFromJournal
|Publication indicators||= 6; : 2016 = 1.147; : 2015 = 2.252 (2) - 2015=2.091 (5)|
|Citation count*||1 (2016-06-01)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.