The influence of fluorine position on the properties of fluorobenzoxaboroles

Agnieszka Adamczyk-Woźniak , Małgorzata K. Cabaj , Paulina M. Dominiak , Patrycja Gajowiec , Błażej Gierczyk , Jacek Lipok , Łukasz Popenda , Grzegorz Schroeder , Ewelina Tomecka , Piotr Urbański , Dorota Wieczorek , Andrzej Sporzyński


5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pKa and multinuclear NMR characterization. The molecular and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690.
Author Agnieszka Adamczyk-Woźniak (FC / DPC)
Agnieszka Adamczyk-Woźniak,,
- Department Of Physical Chemistry
, Małgorzata K. Cabaj
Małgorzata K. Cabaj,,
, Paulina M. Dominiak
Paulina M. Dominiak,,
, Patrycja Gajowiec (FC / DPC)
Patrycja Gajowiec,,
- Department Of Physical Chemistry
, Błażej Gierczyk
Błażej Gierczyk,,
, Jacek Lipok
Jacek Lipok,,
, Łukasz Popenda
Łukasz Popenda,,
, Grzegorz Schroeder
Grzegorz Schroeder,,
, Ewelina Tomecka (FC / IBC / DM)
Ewelina Tomecka,,
- Department Of Microbioanalytics
, Piotr Urbański (FC / DPC)
Piotr Urbański,,
- Department Of Physical Chemistry
et al.`
Journal seriesBioorganic Chemistry, ISSN 0045-2068, (A 25 pkt)
Issue year2015
Publication size in sheets0.5
Keywords in EnglishBenzoxaboroles; Tavaborole; Antifungal activity; Crystal structure
ASJC Classification1605 Organic Chemistry; 3002 Drug Discovery; 1312 Molecular Biology; 1303 Biochemistry
Languageen angielski
1-s2.0-S0045206815000425-main.pdf 993.94 KB
Score (nominal)25
ScoreMinisterial score = 20.0, 05-09-2019, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, 05-09-2019, ArticleFromJournal
Publication indicators WoS Citations = 6; Scopus SNIP (Source Normalised Impact per Paper): 2015 = 0.983; WoS Impact Factor: 2015 = 2.252 (2) - 2015=2.091 (5)
Citation count*1 (2016-06-01)
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