The influence of fluorine position on the properties of fluorobenzoxaboroles

Agnieszka Adamczyk-Woźniak , Małgorzata K. Cabaj , Paulina M. Dominiak , Patrycja Gajowiec , Błażej Gierczyk , Jacek Lipok , Łukasz Popenda , Grzegorz Schroeder , Ewelina Tomecka , Piotr Urbański , Dorota Wieczorek , Andrzej Sporzyński

Abstract

5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pKa and multinuclear NMR characterization. The molecular and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690.
Author Agnieszka Adamczyk-Woźniak (FC / DPC)
Agnieszka Adamczyk-Woźniak,,
- Department Of Physical Chemistry
, Małgorzata K. Cabaj
Małgorzata K. Cabaj,,
-
, Paulina M. Dominiak
Paulina M. Dominiak,,
-
, Patrycja Gajowiec (FC / DPC)
Patrycja Gajowiec,,
- Department Of Physical Chemistry
, Błażej Gierczyk
Błażej Gierczyk,,
-
, Jacek Lipok
Jacek Lipok,,
-
, Łukasz Popenda
Łukasz Popenda,,
-
, Grzegorz Schroeder
Grzegorz Schroeder,,
-
, Ewelina Tomecka (FC / IBC / DM)
Ewelina Tomecka,,
- Department Of Microbioanalytics
, Piotr Urbański (FC / DPC)
Piotr Urbański,,
- Department Of Physical Chemistry
et al.`
Journal seriesBioorganic Chemistry, ISSN 0045-2068, (A 25 pkt)
Issue year2015
Vol60
Pages130-135
Publication size in sheets0.5
Keywords in EnglishBenzoxaboroles; Tavaborole; Antifungal activity; Crystal structure
DOIDOI:10.1016/j.bioorg.2015.05.004
URL http://www.sciencedirect.com/science/article/pii/S0045206815000425
Languageen angielski
File
1-s2.0-S0045206815000425-main.pdf 993.94 KB
Score (nominal)25
ScoreMinisterial score = 20.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2015 = 2.252 (2) - 2015=2.091 (5)
Citation count*1 (2016-06-01)
Cite
Share Share

Get link to the record


* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back