Inhalation devices: from basic science to practical use, innovative vs generic products

Michał Pirożyński , Tomasz Robert Sosnowski

Abstract

Introduction: Inhalation therapy is a convenient method of treating respiratory diseases. The key factors required for inhalation are the preparation of drug carriers (aerosol particles) allowing reproducible dosing during administration. These technical challenges are accomplished with a variety of inhalation devices (inhalers) and medicinal formulations, which are optimized to be easily converted into inhalable aerosols. Areas covered: This review is focused on the most important, but often overlooked, effects, which are required for the reliable and reproducible inhalable drug administration. The effects of patient-related issues that influence inhalation therapy, such as proper selection of inhalers for specific cases is discussed. We also discuss factors that are the most essential if generic inhalation product should be considered equivalent to the drugs with the clinically confirmed efficacy. Expert opinion: Proper device selection is crucial in clinical results of inhalation therapy. The patients’ ability to coordinate inhalation with actuation, generation of optimal flow through the device, use of optimal inspiratory volume, all produces crucial effects on disease control. Also the severity of the disease process effects proper use of inhalers. Interchanging of inhalers can produce potentially conflicting problem regarding efficacy and safety of inhalation therapy.
Author Michał Pirożyński
Michał Pirożyński,,
-
, Tomasz Robert Sosnowski KIPZ
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
Journal seriesExpert Opinion on Drug Delivery, ISSN 1742-5247
Issue year2016
Vol13
No11
Pages1559-1571
Publication size in sheets0.6
Keywords in Englishdrug administration, inhalation, aerosol, bioequivalence, drug approval, drug delivery systems, inhalers, generic drugs, lung deposition, nebulizers and vaporizers,
DOIDOI:10.1080/17425247.2016.1198774
URL http://dx.doi.org/10.1080/17425247.2016.1198774
Languageen angielski
Score (nominal)45
ScoreMinisterial score = 45.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 45.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 5.657 (2) - 2016=5.557 (5)
Citation count*8 (2018-02-19)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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