Polysaccharide nanoparticles for controlled delivery of cancer drugs

Iga Wasiak , Tomasz Ciach

Abstract

Development of the techniques of designing and production of controlled drug deliver system is one of the most important area of contemporary medicine and science. Conventionally drug carrier are ineffective due to numerous of limitations. This disadvantages include nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability, low therapeutic indices and partial degradation as a consequence of lack of control over concentration. It makes they uncomfortable for patients and cause side effects due to affect both cancerous and normal cells. The ideal drug carrier should be inert, biocompatible, biodegradable, nontoxic efficient in loading and release of drug and simply to administer and produce. Polysaccharide as natural biomaterials, polysaccharides are highly stable, safe, non-toxic, hydrophilic and biodegradable. In addition, polysaccharides have abundant resources in nature and low cost in their processing. Mentioned properties satisfy the requirements for ideal drug carrier and are believed to be sufficient materials for biomedical applications. Nanoparticle drug delivery systems have outstanding advantages: they can pass through the smallest capillary vessels and avoid rapid clearance by phagocytes so that their duration in blood stream is greatly prolonged; they can penetrate cells and tissue gap to arrive at target organs such as liver, spleen, lung, spinal cord and lymph; they could show controlled release properties due to the biodegradability, pH, ion and/or temperature sensibility of materials; they can improve the utility of drugs and reduce toxic side effects; etc. As drug delivery system, nanoparticles can entrap drugs or biomolecules into their interior structures and/or absorb drugs or biomolecules onto their exterior surfaces. Now a days, nanoparticles have been widely investigated to deliver drugs, polypeptides, proteins, vaccines, nucleic acids, genes and so on. Nanoparticle drug delivery systems have shown huge potential in biological, medical and pharmaceutical applications. The aim of this study was to prepared polysaccharide nanoparticles in simple procedure in water solution at room temperature. Nanoparticles are formed due to hydrophobic – hydrophilic interactions, this process is verified by using light scattering technique. Obtained nanoparticles are very stabile and poses narrow size distribution. Produced nanoparticles can be lyophilized to dry powder and resuspended in water again. Cytotoxicity of produced nanoparticles was tested with mouse fibroblast cells, particles showed to be non toxic even at fairly high concentration. Then doxorubicine was tested as a potential anticancer drug to be encapsulated, it was covalently attached to nanoparticles via amine group - Schiff base bound. Obtained drug loaded NPs were stable (t½ 48h).
Author Iga Wasiak (FCPE / DBBE)
Iga Wasiak,,
- Department of Biotechnology and Bioprocess Engineering
, Tomasz Ciach (FCPE / DBBE)
Tomasz Ciach,,
- Department of Biotechnology and Bioprocess Engineering
Pages172-172
Publication size in sheets0.3
Book VI Krajowa Konferencja Nanotechnologii, 2013, ul. Piastów 17, Szczecin 70-310, Przedsiębiorstwo Produkcyjno-Handlowe ZAPOL Dmochowski, Sobczyk, Sp. J., ISBN 978-83-7518-571-3, 181 p.
Keywords in Polishnanocząstki polisacharydowe, leczenie nowotworów
Keywords in Englishpolysaccharide nanoparticles, cancer treatment
Languageen angielski
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WasiakI.,Szczecin 1.pdf 31.46 KB
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