Nanoengineered biocomposite tricomponent polymer based matrices for bone tissue engineering
Ewa Kijeńska , Zhang Sai , Molamma P. Prabhakaran , Seeram Ramakrishna , Wojciech Święszkowski
AbstractNanoengineered biodegradable constructs based on synthetic and natural polymers enriched with hydroxyapatite (HA) nanoparticles have been found to mimic the extracellular matrix of bone tissue. The main objective of this study was to create biocomposite nanostructured scaffolds by incorporating collagen and HA nanoparticles into poly(L-lactic acid)-co-poly(epsilon-caprolactone) by electrospinning. The fiber diameter of the composite PLCL/Col and PLCL/Col/HA fibers was smaller compared to PLCL. In vitro biocompatibility of the scaffolds studied using human fetal osteoblasts and EDX analysis showed high deposition of calcium on PLCL/Col/HA. The results shows that PLCL/Col/HA nanofibrous constructs have huge potential as substrates for bone regeneration.
|Journal series||International Journal of Polymeric Materials, ISSN 0091-4037|
|Publication size in sheets||0.5|
|Keywords in English||Collagen; mineralization; nanofibers; nanohydroxyapatite; osteoblasts|
|ASJC Classification||; ;|
|Score|| = 20.0, 10-06-2020, ArticleFromJournal|
= 30.0, 10-06-2020, ArticleFromJournal
|Publication indicators||= 16; : 2016 = 0.57; : 2016 = 1.515 (2) - 2016=1.237 (5)|
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