Nanoengineered biocomposite tricomponent polymer based matrices for bone tissue engineering

Ewa Kijeńska , Zhang Sai , Molamma P. Prabhakaran , Seeram Ramakrishna , Wojciech Święszkowski


Nanoengineered biodegradable constructs based on synthetic and natural polymers enriched with hydroxyapatite (HA) nanoparticles have been found to mimic the extracellular matrix of bone tissue. The main objective of this study was to create biocomposite nanostructured scaffolds by incorporating collagen and HA nanoparticles into poly(L-lactic acid)-co-poly(epsilon-caprolactone) by electrospinning. The fiber diameter of the composite PLCL/Col and PLCL/Col/HA fibers was smaller compared to PLCL. In vitro biocompatibility of the scaffolds studied using human fetal osteoblasts and EDX analysis showed high deposition of calcium on PLCL/Col/HA. The results shows that PLCL/Col/HA nanofibrous constructs have huge potential as substrates for bone regeneration.
Author Ewa Kijeńska (FMSE / DMD)
Ewa Kijeńska,,
- Division of Materials Design
, Zhang Sai
Zhang Sai,,
, Molamma P. Prabhakaran - [National University of Singapore]
Molamma P. Prabhakaran,,
, Seeram Ramakrishna - [National University of Singapore]
Seeram Ramakrishna,,
, Wojciech Święszkowski (FMSE / DMD)
Wojciech Święszkowski,,
- Division of Materials Design
Journal seriesInternational Journal of Polymeric Materials, ISSN 0091-4037
Issue year2016
Publication size in sheets0.5
Keywords in EnglishCollagen; mineralization; nanofibers; nanohydroxyapatite; osteoblasts
ASJC Classification2507 Polymers and Plastics; 1500 General Chemical Engineering; 1602 Analytical Chemistry
Languageen angielski
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 20.0, 10-06-2020, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 10-06-2020, ArticleFromJournal
Publication indicators Scopus Citations = 16; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.57; WoS Impact Factor: 2016 = 1.515 (2) - 2016=1.237 (5)
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