Biodegradation of bicomponent PCL/gelatin and PCL/collagen nanofibers electrospun from alternative solvent system

Judyta Dulnik , Piotr Denis , Paweł Sajkiewicz , Dorota Kołbuk , Emilia Choińska

Abstract

Bicomponent polycaprolactone/gelatin and polycaprolactone/collagen nanofibers formed by electrospinning using various solvents were subjected to biodegradation and compared. Hexafluoroisopropanol (HFIP) was used as a reference solvent, while the second, alternative solvent system was the mixture of acetic acid (AA) with formic acid (FA). Biodegradation of investigated materials was manifested mainly by the gelatin leaching, including collagen which is indeed denaturated to gelatin during electrospinning, leading to nanofibers erosion. There was no molecular degradation of PCL during 90 days of biodegradation procedure as deduced from no change in the elongation stress at break. The rate of biopolymer leaching was very fast from all materials during the first 24 h of biodegradation, being related to surface leaching, followed by a slower rate leaching from deeper material layers. Mass measurements showed much faster biopolymer leaching from nanofibers electrospun from AA/FA than from HFIP because of strongly emulsive nature of the solution in the former case. Irrespective of the solvent used, the leaching rate increased with initial content of gelatin. The analysis of Young modulus during biodegradation indicated complex mechanism of changes, including biopolymer mass loss, increase of PCL crystallinity and partial gelatin renaturation
Author Judyta Dulnik - Polish Academy of Sciences (PAN)
Judyta Dulnik,,
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, Piotr Denis - Polish Academy of Sciences (PAN)
Piotr Denis,,
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, Paweł Sajkiewicz - Polish Academy of Sciences (PAN)
Paweł Sajkiewicz,,
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, Dorota Kołbuk - Polish Academy of Sciences (PAN)
Dorota Kołbuk,,
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, Emilia Choińska ZPM
Emilia Choińska,,
- Division of Materials Design
Journal seriesPolymer Degradation and Stability, ISSN 0141-3910
Issue year2016
Vol130
Pages10-21
Publication size in sheets0.55
Keywords in PolishDwuskładnikowe nanowłókna, biodegradacja
Keywords in Englishbicomponent nanofibers, biodegradation, biopolymer
DOIDOI:10.1016/j.polymdegradstab.2016.05.022
URL http://www.sciencedirect.com/science/article/pii/S0141391016301525
Languageen angielski
Score (nominal)35
ScoreMinisterial score = 35.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.386 (2) - 2016=3.72 (5)
Citation count*12 (2018-07-13)
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