Investigation of the BMP-2 adsorption to different solvent-treated 3D PCL scaffolds

Alicja Kosik-Kozioł , Vaquette Cedryck , Graham Elizabeth , Adrian Chlanda , Kumar Sudhees , Ivanovski Saso , Wojciech Święszkowski , Hutmacher Dietmar


The application of bone morphogenic proteins (BMPs) is a prominent area of research for application in bone tissue engineering. This biological protein is generally combined with a gel or a collagenous carrier to facilitate its delivery. However, this results in poorly controlling the release of the bioactive cue potentially leading to significant adverse effects. A novel strategy involves the absorption of the BMP onto a biomaterial scaffold in order to alter the release kinetic. In this study, we investigated the impact of surface modification of polycaprolactone (PCL) 3D printed scaffolds onto BMP-2 adsorption efficacy and release.
Author Alicja Kosik-Kozioł (FMSE / DMD)
Alicja Kosik-Kozioł,,
- Division of Materials Design
, Vaquette Cedryck - Queensland University of Technology, Australia
Vaquette Cedryck,,
, Graham Elizabeth - Queensland University of Technology, Australia
Graham Elizabeth,,
, Adrian Chlanda (FMSE / DMD)
Adrian Chlanda,,
- Division of Materials Design
, Kumar Sudhees - Griffith University, Australia
Kumar Sudhees,,
, Ivanovski Saso - Griffith University, Australia
Ivanovski Saso,,
, Wojciech Święszkowski (FMSE / DMD)
Wojciech Święszkowski,,
- Division of Materials Design
, Hutmacher Dietmar - Queensland University of Technology, Australia
Hutmacher Dietmar,,
Journal seriesFrontiers in Bioengineering and Biotechnology, ISSN , e-ISSN 2296-4185
Issue year2016
Publication size in sheets0.3
Conference10th World Biomaterials Congress, 17-05-2016 - 22-05-2016, Montreal, Kanada
Keywords in Englishbiomaterial, growth factor, protein, 3D scaffold
Languageen angielski
Score (nominal)0
ScoreMinisterial score = 0.0, 05-09-2019, ArticleFromJournal
Ministerial score (2013-2016) = 0.0, 05-09-2019, ArticleFromJournal
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