Structure and hemocompatibility of nanocrystalline titanium nitride produced under glow-discharge conditions

Agnieszka Sowińska , Elżbieta Czarnowska , Michał Tarnowski , Justyna Witkowska , Tadeusz Wierzchoń


Significant efforts are being made towards developing novel antithrombotic materials. The purpose of the presented study was to characterize two variants of nitrided surface layers produced on alloy Ti-6Al-4V in different areas of low-temperature plasma – at the plasma potential (TiNp) or at the cathode potential (TiNc). The layers were characterized in terms of their microstructure, surface topography and wettability, and platelet response to the environment of different pH. The produced layers were of the TiN + Ti2N + αTiN-type, but the layer produced at the plasma potential was thinner, smoother and had lower surface free energy compared with that produced at the cathode potential. Biological evaluation demonstrated more fibrinogen buildup, less platelet adhesion and aggregation, and fewer strongly activated platelets on the TiNp surface compared with those parameters on the TiNc surface and on the titanium alloy in its initial state. Interestingly, both surface types were significantly resistant to fibrinogen adsorption and platelet adhesion in the environment of lower pH. In conclusion, the nitrided surface layer produced at the plasma potential is a promising material and this basic information is critical for further development of hemocompatible materials.
Author Agnieszka Sowińska - Instytut „Pomnik – Centrum Zdrowia Dziecka” (CZD)
Agnieszka Sowińska,,
, Elżbieta Czarnowska - Instytut „Pomnik – Centrum Zdrowia Dziecka” (CZD)
Elżbieta Czarnowska,,
, Michał Tarnowski (FMSE / DSE)
Michał Tarnowski,,
- Division of Surface Engineering
, Justyna Witkowska (FMSE / DSE)
Justyna Witkowska,,
- Division of Surface Engineering
, Tadeusz Wierzchoń (FMSE / DSE)
Tadeusz Wierzchoń,,
- Division of Surface Engineering
Journal seriesApplied Surface Science, ISSN 0169-4332, (A 35 pkt)
Issue year2018
Publication size in sheets0.5
Keywords in Englishnitrided surface layer; glow-discharge nitriding; nanotopography; hemocompatiblity;
ASJC Classification2508 Surfaces, Coatings and Films
Languageen angielski
Structure and hemocompatibility of nanocrystalline titanium nitride.pdf 2.47 MB
Score (nominal)35
ScoreMinisterial score = 35.0, 11-03-2019, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 11-03-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.225; WoS Impact Factor: 2017 = 4.439 (2) - 2017=3.743 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.