Poly(glycerol sebacate) as prepolymer material for biomedical applications - synthesis and purification method

Michał Wrzecionek , Michał Więcław , Agnieszka Gadomska-Gajadhur


Polyesters are very interesting materials for scientists looking for biodegradable and biocompatible materials. Currently, one of the newest polyesters, which could be biomaterial for tissue regeneration is poly(glycerol sebacate) (pgs). pgs is a biocompatible, biodegradable, non-immunogenic and non-toxic material. It is postulated to use this polymer with suitable properties as follows: cell scaffold in soft tissue engineering, drug carrier, surgical sealants, and as a contact surface for biomedical sensors. Most of the works are focused on the synthesis of the crosslinked polymer (no isolation of the prepolymer) adapted to perform one function. In our work, we focused on developing a synthesis and purification of a non-crosslinked product, which is called prepolymer. The equipment for industrial polymer production has been proposed. The material was characterized by ir spectroscopy, nmr spectroscopy and the acid and ester numbers were determined for delimitation of esterification degree. The analysis of the final product confirms the purity of the prepgs. The material produced by us can be processed in a simple way for functionalization. This is an incredible advantage appreciated by manufacturers of medical devices.
Author Michał Wrzecionek (FC / CPCT)
Michał Wrzecionek,,
- Chair Of Polymer Chemistry And Technology
, Michał Więcław (FC / CPCT)
Michał Więcław,,
- Chair Of Polymer Chemistry And Technology
, Agnieszka Gadomska-Gajadhur (FC / CPCT)
Agnieszka Gadomska-Gajadhur,,
- Chair Of Polymer Chemistry And Technology
Publication size in sheets0.6
Book EYEC Monograph: 8th European Young Engineers Conference, 2019, Politechnika Warszawska, Wydział Inżynierii Chemicznej i Procesowej, ISBN 978-83-936575-7-5, 364 p.
Keywords in Englishpoly(glycerol sebacate), prepolymer, synthesis, purification, optimization
URL https://www.eyec.ichip.pw.edu.pl/wp-content/uploads/Monograph-8th-EYEC.pdf
Languageen angielski
wdpb_monografie_pliki_plik_monografia_165_org.pdf 640.23 KB
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