Production of 3D printed polylactide scaffolds with surface grafted hydrogel coatings

Piotr Kowalczyk , Paulina Anna Trzaskowska , Ilona Łojszczyk , Rafał Kamil Podgórski , Tomasz Ciach

Abstract

The aim of this work was to elaborate the 3D printed polylactide (PLA) polymeric scaffolds and, subsequently, study the possibility of coating thereof with a biomedical polyvinylpyrrolidone (PVP) hydrogel through the previously patented protocol. Such materials have a potential to be applied in biomedical engineering, e.g. for tissue regeneration. PVP layer according to the present paper could constitute a useful biocompatible supporting layer for drug delivering implant surfaces of any shape. Polylactide (PLA) both in forms of flat foils and 3Dprinted scaffolds was used to be coated with PVP layer with the Fenton-type reaction that enables the polymeric scaffold grafting with hydrogel in two easy steps. The study revealed that PVP was successfully grafted to PLA substrates. Most optimal parameters for PVP grafting process were selected. The PLA-PVP materials were found to be hydrophilic and non-toxic which is promising considering their biomedical application. The method comprising well-tested PLA scaffolds printing and then grafting them with PVP layer has a promising potential to be brought in to the industrial production due to its simplicity.
Author Piotr Kowalczyk (FCPE / DBBE)
Piotr Kowalczyk,,
- Department of Biotechnology and Bioprocess Engineering
, Paulina Anna Trzaskowska (FCPE / DBBE) - CENTRAL LABORATORY OF CEZAMAT (CEZAMAT)
Paulina Anna Trzaskowska,,
- Department of Biotechnology and Bioprocess Engineering
, Ilona Łojszczyk (FCPE / DBBE)
Ilona Łojszczyk,,
- Department of Biotechnology and Bioprocess Engineering
, Rafał Kamil Podgórski (FCPE / DBBE)
Rafał Kamil Podgórski,,
- Department of Biotechnology and Bioprocess Engineering
, Tomasz Ciach (FCPE / DBBE)
Tomasz Ciach,,
- Department of Biotechnology and Bioprocess Engineering
Journal seriesColloids and Surfaces B-Biointerfaces, ISSN 0927-7765, (A 35 pkt)
Issue year2019
Vol179
Pages136-142
Publication size in sheets0.5
Keywords in Englishhydrogels, polyvinylpyrrolidone, surface modification, scaffolds, 3D printing
ASJC Classification1505 Colloid and Surface Chemistry; 1606 Physical and Theoretical Chemistry; 3110 Surfaces and Interfaces; 2700 General Medicine; 1305 Biotechnology
DOIDOI:10.1016/j.colsurfb.2019.03.069
URL https://www.sciencedirect.com/science/article/pii/S0927776519302188
Languageen angielski
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Kowalczyk P. (i in.) - Production of 3D....pdf of 08-04-2019
2.68 MB
Score (nominal)35
ScoreMinisterial score = 35.0, 05-09-2019, ArticleFromJournal
Publication indicators Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.101; WoS Impact Factor: 2017 = 3.997 (2) - 2017=4.294 (5)
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