Surface properties of pulmonary surfactant in the presence of metal oxide nanoparticles
Dorota Kondej , Tomasz Robert Sosnowski
AbstractThis study was aimed to evaluate the influence of metal oxide nanoparticles (MON) on the surface properties of the pulmonary surfactant (PS), which constitutes the first barrier separating the lung tissue from inhaled air. Changes in surface pressure over time in the presence of aluminum oxide, zinc oxide and cerium oxide nanoparticles (Sigma-Aldrich) were tested using DeltaPi microtensiometer (Kibron Inc., Finland). The animal-derived surfactant preparation (Beractantum; Abbott Laboratories, France) was used as model PS. The tests were carried out at different MON concentrations (ranging up to 1 mg/ml) with the constant concentration of PS solution (1.25 mg phospholipids/ml). It was found that MON caused an increase in surface pressure at the liquid–air interface. The intensity of these changes depends on the chemical structure, size distribution, specific surface area and concentration of MON in the liquid phase. The largest increase in surface pressure (8.0 ± 1.3 mN/m) was observed after 600 s in the presence of aluminum oxide nanoparticles, which were characterized by the smallest dimensions (13 nm; TEM) and the largest surface area (139.8 m2/g; BET). Results show that MON may influence the PS surface activity in vivo and cause a disturbance of biochemical processes in the respiratory system. This paper was prepared on the basis of the results of the task No. 2.Z.07 carried out within the National Programme “Improvement of safety and working conditions” partly supported in 2014-2016 within the scope of state services – by the Ministry of Labour and Social Policy. CIOP-PIB was the Programme's main co-ordinator.
|Journal series||Toxicology Letters, ISSN 0378-4274|
|Publication size in sheets||0.3|
|Conference||52nd Congress Of The European Societies Of Toxicology (EUROTOX 2016), 04-09-2016 - 07-09-2016, Seville, Hiszpania|
|Publication indicators||= 0; : 2016 = 1.201; : 2016 = 3.858 (2) - 2016=3.807 (5)|
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