Critical assessment of the quantitative criteria used in the comparison of nebulizers

Tomasz Robert Sosnowski

Abstract

Inhalation of aerosols from nebulizers remains an important method of drug delivery in treating diseases of the respiratory system. To be effective, aerosol droplets generated in nebulizers must hold certain size distribution which allow them to pass the oropharynx and be distributed in the bronchial tree. The assessment of droplet size distribution can be made by several experimental techniques and various quantitative parameters are used to characterize the operation of nebulizing devices. In this paper the physical meaning and usefulness of standard and non-standard quantitative parameters (i.e., MMAD, Dv50, FPF, GSD, Span) are discussed and followed by conclusions regarding their application to compare different nebulizers in the most reliable way
Author Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
Journal seriesEC Pulmonology and Respiratory Medicine, (0 pkt)
Issue year2019
Vol8
No9
Pages656-662
Publication size in sheets0.5
Keywords in Englishnebulizers, MMAD, Dv50, FPF, GSD, span
URL https://www.ecronicon.com/ecprm/pdf/ECPRM-08-00459.pdf
Languageen angielski
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Sosnowski T.R. - Critical assessment of....pdf 706.03 KB
Score (nominal)5
Score sourcejournalList
ScoreMinisterial score = 5.0, 20-02-2020, ArticleFromJournal
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