Long-period gratings and microcavity in-line mach zehnder interferometers as highly sensitive optical fiber platforms for bacteria sensing

Tinko Eftimov , Monika Janik , Marcin Koba , Mateusz Jakub Śmietana , Predrag Mikulic , Wojtek J. Bock


Selected optical fiber sensors offer extraordinary sensitivity to changes in external refractive (RI), which make them promising for label-free biosensing. In this work the most sensitive ones, namely long-period gratings working at (DTP-LPG) and micro-cavity in-line Mach-Zehnder interferometers (µIMZI) are discussed for application in bacteria sensing. We describe their working principles and RI sensitivity when operating in water environments, which is as high as 20,000 nm/RIU (Refractive index unit) for DTP-LPGs and 27,000 nm/RIU for µIMZIs. Special attention is paid to the methods to enhance the sensitivity by etching and nano-coatings. While the DTP-LPGs offer a greater interaction length and sensitivity to changes taking place at their surface, the µIMZIs are best suited for investigations of sub-nanoliter and picoliter volumes. The capabilities of both the platforms for bacteria sensing are presented and compared for strains of Escherichia coli, lipopolysaccharide E. coli, outer membrane proteins of E. coli, and Staphylococcus aureus. While DTP-LPGs have been more explored for bacteria detection in 102 –106 Colony Forming Unit (CFU)/mL for S. aureus and 103 –109 CFU/mL for E. coli, the µIMZIs reached 102 –108 CFU/mL for E. coli and have a potential for becoming picoliter bacteria sensors.
Publication typeReview
Author Tinko Eftimov
Tinko Eftimov,,
, Monika Janik (FEIT / MO)
Monika Janik,,
- The Institute of Microelectronics and Optoelectronics
, Marcin Koba (FEIT / MO)
Marcin Koba,,
- The Institute of Microelectronics and Optoelectronics
, Mateusz Jakub Śmietana (FEIT / MO)
Mateusz Jakub Śmietana,,
- The Institute of Microelectronics and Optoelectronics
, Predrag Mikulic
Predrag Mikulic,,
, Wojtek J. Bock
Wojtek J. Bock,,
Journal seriesSensors, [SENSORS-BASEL], ISSN 1424-8220, e-ISSN 1424-3210
Issue year2020
Publication size in sheets0.85
Article number3772
ASJC Classification1303 Biochemistry; 1602 Analytical Chemistry; 2208 Electrical and Electronic Engineering; 3107 Atomic and Molecular Physics, and Optics
Languageen angielski
Score (nominal)50
Score correctionScore reduced to 50% (because of special publication type)
Score sourcejournalList
ScoreMinisterial score = 50.0, 25-08-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.393; WoS Impact Factor: 2018 = 3.031 (2) - 2018=3.302 (5)
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