Dopamine/2-Phenylethylamine Sensitivity of Ion-Selective Electrodes Based on Bifunctional-Symmetrical Boron Receptors

Martyna Durka , Krzysztof Durka , Agnieszka Adamczyk-Woźniak , Wojciech Wróblewski

Abstract

Piperazine-based compounds bearing two phenylboronic acid or two benzoxaborole groups (PBPA and PBBB) were applied as dopamine receptors in polymeric membranes (PVC/DOS) of ion-selective electrodes. The potentiometric sensitivity and selectivity of the sensors towards dopamine were evaluated and compared with the results obtained for 2-phenylethylamine. Since the developed electrodes displayed strong interference from 2-phenylethylamine, single-molecule geometry optimizations were performed using the density functional theory (DFT) method in order to investigate the origin of dopamine/2-phenylethylamine selectivity. The results indicated that phenylboronic acid and benzoxaborole receptors bind dopamine mainly through the dative B–N bond (like 2-phenylethylamine) and the potentiometric selectivity is mainly governed by the higher lipophilicity of 2-phenylethylamine
Author Martyna Durka (FC / CMB)
Martyna Durka,,
- Chair of Medical Biotechnology
, Krzysztof Durka (FC / DPC)
Krzysztof Durka,,
- Department Of Physical Chemistry
, Agnieszka Adamczyk-Woźniak (FC / DPC)
Agnieszka Adamczyk-Woźniak,,
- Department Of Physical Chemistry
, Wojciech Wróblewski (FC / CMB)
Wojciech Wróblewski,,
- Chair of Medical Biotechnology
Journal seriesSensors, [SENSORS-BASEL], ISSN 1424-8220, (N/A 100 pkt)
Issue year2019
Vol19
No2, 283
Pages1-11
Publication size in sheets0.5
Keywords in Englishion-selective electrodes; organoboron receptors; dopamine
ASJC Classification2208 Electrical and Electronic Engineering; 1303 Biochemistry; 3107 Atomic and Molecular Physics, and Optics; 1602 Analytical Chemistry
DOIDOI:10.3390/s19020283
URL https://www.mdpi.com/1424-8220/19/2/283
Languageen angielski
File
sensors-19-00283.pdf 1.05 MB
Score (nominal)100
ScoreMinisterial score = 100.0, 23-09-2019, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.393; WoS Impact Factor: 2017 = 2.475 (2) - 2017=3.014 (5)
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