A particle technology approach toward designing dry-powder inhaler formulations for personalized medicine in respiratory diseases

Kazunori Kadota , Tomasz Robert Sosnowski , Satoshi Tobita , Isao Tachibana , Jun Yee Tse , Hiromasa Uchiyama , Yuichi Tozuka

Abstract

Compared with oral and parenteral formulations, inhaled formulations are attractive because of their great benefit and potential to enhance therapeutic effects of medications. Among the available inhaled formulations, powders used with dry-powder inhalers (DPIs) have become a preferred option because of their many advantages over other inhaled formulations. Additionally, a powder technological approach is required and available for sophisticated design of DPI formulations. To provide appropriate treatment using a DPI formulation, inhaled particles containing drugs should be delivered to the appropriate sites in the lungs of individual patients. It is indispensable that the design of DPI formulations specify particle properties suitable for a specific disease and the appropriate positions in the lungs to which the inhaled particles must be delivered. This article focuses on the current particle technological approach toward designing DPI formulations and numerical simulation analysis of behavior and deposition of inhaled particles in the lungs. As a future perspective from the viewpoint of pharmaceutical particle technology, a combination of experimental and simulation approaches is expected to improve the ability to obtain maximum lung delivery as well as target the site of deposition in the lungs of individual patients.
Author Kazunori Kadota
Kazunori Kadota,,
-
, Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
, Satoshi Tobita
Satoshi Tobita,,
-
, Isao Tachibana
Isao Tachibana,,
-
, Jun Yee Tse
Jun Yee Tse,,
-
, Hiromasa Uchiyama
Hiromasa Uchiyama,,
-
, Yuichi Tozuka
Yuichi Tozuka,,
-
Journal seriesAdvanced Powder Technology, ISSN 0921-8831, e-ISSN 1568-5527
Issue year2020
Vol31
No1
Pages219-226
Publication size in sheets0.5
Keywords in Englishaerodynamic particle size, computational fluid dynamics, computed tomography, design of experiment, dry-powder inhaler
ASJC Classification1500 General Chemical Engineering; 2211 Mechanics of Materials
DOIDOI:10.1016/j.apt.2019.10.013
URL https://www.sciencedirect.com/science/article/pii/S0921883119303668?via%3Dihub#aep-article-footnote-id2
Languageen angielski
File
Kadota K. (i in.) - A particle technology...pdf 1.22 MB
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 07-09-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; WoS Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.271; WoS Impact Factor: 2018 = 3.25 (2) - 2018=3.101 (5)
Citation count*2 (2020-09-20)
Additional fields
UwagiThis article is submitted for Special Issue: the 30th Anniversary Collection ofAdvanced Powder Technology
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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