.; Influence of biodegradable polymer coatings on corrosion, cytocompatibility and cell functionality of Mg-2.0Zn-0.98Mn magnesium alloy

Agnieszka Witecka , A. Yamamoto , Joanna Idaszek , Adrian Chlanda , Wojciech Święszkowski


Four kinds of biodegradable polymers were employed to prepare bioresorbable coatings on Mg-2.OZn-0.98Mn (ZM21) alloy to understand the relationship between polymer characteristics, protective effects on substrate corrosion, cytocompatibility and cell functionality. Poly-L-lactide (PLLA), poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) or poly(lactic-co-glycolic) acid (PLGA) was spin-coated on ZM21, obtaining a smooth, non-porous coating less than 0.5 mu m in thickness. Polymer coating characterization, a degradation study, and biocompatibility evaluations were performed. After 4 w of immersion into cell culture medium, degradation of PLGA and PLLA coatings were confirmed by ATR-FTIR observation. The coatings of PLLA, PHB and PHBV, which have lower water permeability and slower degradation than PLGA, provide better suppression of initial ZM21 degradation and faster promotion of human osteosarcoma cell growth and differentiation. (C) 2016 Elsevier B.V. All rights reserved.
Author Agnieszka Witecka (FMSE / DMD)
Agnieszka Witecka,,
- Division of Materials Design
, A. Yamamoto - [National Institute for Materials Science Tsukuba]
A. Yamamoto,,
, Joanna Idaszek (FMSE)
Joanna Idaszek,,
- Faculty of Materials Science and Engineering
, Adrian Chlanda (FMSE / DMD)
Adrian Chlanda,,
- Division of Materials Design
, Wojciech Święszkowski (FMSE / DMD)
Wojciech Święszkowski,,
- Division of Materials Design
Journal seriesColloids and Surfaces B-Biointerfaces, ISSN 0927-7765
Issue year2016
Publication size in sheets0.5
Keywords in EnglishBiodegradable metal; Magnesium alloy; Biodegradable polymer; SaOS-2 differentiation; Calcification
ASJC Classification1505 Colloid and Surface Chemistry; 1606 Physical and Theoretical Chemistry; 3110 Surfaces and Interfaces; 2700 General Medicine; 1305 Biotechnology
URL http://www.sciencedirect.com/science/article/pii/S0927776516302788
Languageen angielski
Score (nominal)35
Score sourcejournalList
ScoreMinisterial score = 35.0, 25-06-2020, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 25-06-2020, ArticleFromJournal
Publication indicators Scopus Citations = 18; WoS Citations = 11; GS Citations = 27.0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.327; WoS Impact Factor: 2016 = 3.887 (2) - 2016=4.295 (5)
Citation count*27 (2020-09-01)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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