.; Influence of biodegradable polymer coatings on corrosion, cytocompatibility and cell functionality of Mg-2.0Zn-0.98Mn magnesium alloy
Agnieszka Witecka , A. Yamamoto , Joanna Idaszek , Adrian Chlanda , Wojciech Święszkowski
AbstractFour kinds of biodegradable polymers were employed to prepare bioresorbable coatings on Mg-2.OZn-0.98Mn (ZM21) alloy to understand the relationship between polymer characteristics, protective effects on substrate corrosion, cytocompatibility and cell functionality. Poly-L-lactide (PLLA), poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) or poly(lactic-co-glycolic) acid (PLGA) was spin-coated on ZM21, obtaining a smooth, non-porous coating less than 0.5 mu m in thickness. Polymer coating characterization, a degradation study, and biocompatibility evaluations were performed. After 4 w of immersion into cell culture medium, degradation of PLGA and PLLA coatings were confirmed by ATR-FTIR observation. The coatings of PLLA, PHB and PHBV, which have lower water permeability and slower degradation than PLGA, provide better suppression of initial ZM21 degradation and faster promotion of human osteosarcoma cell growth and differentiation. (C) 2016 Elsevier B.V. All rights reserved.
|Journal series||Colloids and Surfaces B-Biointerfaces, ISSN 0927-7765|
|Publication size in sheets||0.5|
|Keywords in English||Biodegradable metal; Magnesium alloy; Biodegradable polymer; SaOS-2 differentiation; Calcification|
|Score|| = 35.0, 28-11-2017, ArticleFromJournal|
= 35.0, 28-11-2017, ArticleFromJournal
|Publication indicators||: 2016 = 3.887 (2) - 2016=4.295 (5)|
|Citation count*||12 (2018-06-21)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.