Poly-L-lactide scaffolds with super pores obtained by freeze-extraction method

Monika Budnicka , Dorota Kołbuk , Paweł Ruśkowski , Agnieszka Gadomska-Gajadhur

Abstract

A nonplanar polylactide scaffold to be used in tissue engineering was obtained by freeze-extraction method. Properties of the scaffold were modified by adding Eudragit® E100. The impact of the modification on morphology, porosity and pore size, mass absorbability, mechanical properties was determined. Scanning electron microscopy (SEM), hydrostatic weighing test, static compression test was used to this end. The chemical composition of the scaffold was defined based on infrared spectroscopy (FTIR) and energy-dispersive X-ray spectroscopy (EDX). Biocompatibility was confirmed by quantitative tests and microscopic observation. The obtained results show that the obtained scaffolds may be applied as a carrier of hydrophilic cellular growth factors for more efficient tissue regeneration.

Author Monika Budnicka (FC / CPCT)
Monika Budnicka,,
- Chair Of Polymer Chemistry And Technology
, Dorota Kołbuk - [Institute of Fundamental Technological Research of the Polish Academy of Sciences]
Dorota Kołbuk,,
-
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, Paweł Ruśkowski (FC / CPCT)
Paweł Ruśkowski,,
- Chair Of Polymer Chemistry And Technology
, Agnieszka Gadomska-Gajadhur (FC / CPCT)
Agnieszka Gadomska-Gajadhur,,
- Chair Of Polymer Chemistry And Technology
Journal seriesJournal of Biomedical Materials Research Part B-Applied Biomaterials, [Journal of Biomedical Materials Research - Part B Applied Biomaterials], ISSN 1552-4973, e-ISSN 1552-4981
Issue year2020
Pages1-12
Publication size in sheets0.55
ASJC Classification2204 Biomedical Engineering; 2502 Biomaterials
DOIDOI:10.1002/jbm.b.34642
URL https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.34642
Languageen angielski
File
jbm.b.34642.pdf 18.18 MB
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 22-08-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; WoS Citations = 0; GS Citations = 1.0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.915; WoS Impact Factor: 2018 = 2.674 (2) - 2018=2.908 (5)
Citation count*1 (2020-09-17)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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