Electrolyte alginate/poly-l-lysine membranes for connective tissue development
Alicja Kosik , Urszula Luchowska , Wojciech Święszkowski
AbstractThe aim of this study was to change the surface of sodium alginate hydrogel by electrostatic binding of poly-l-lysine (PLL) in order to provide more advantageous conditions for connective tissue development. Its impact on L929 mouse fibroblast adhesion, morphology and viability was investigated. Analysis of the material microstructure has shown that performed modification increased surface roughness. It also altered the swelling properties of alginate hydrogel, resulting in less rapid water absorption. Mouse fibroblasts seeded on regular alginate and alginate modified with PLL exhibited different behaviour. The presence of PLL turned out to promote cell adhesion and F-actin spreading, resulting in significantly increased number of viable cells 96 h after seeding.
|Journal series||Materials Letters, ISSN 0167-577X|
|Publication size in sheets||0.5|
|Keywords in English||Alginate; Poly-l-lysine; Electrolyte membranes; Cell adhesion|
|Score|| = 35.0, 28-11-2017, ArticleFromJournal|
= 35.0, 28-11-2017, ArticleFromJournal
|Publication indicators||: 2016 = 2.572 (2) - 2016=2.426 (5)|
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