Magnetic field-assisted selective delivery of doxorubicin to cancer cells using magnetoliposomes as drug nanocarriers

Aleksandra Szuplewska , Aleksandra Rękorajska (Joniec) , Edyta Pocztańska , Paweł Krysiński , Artur Dybko , Michał Chudy


Magnetoliposomes are promising candidates for the development of selective drug delivery systems in the treatment of cancer. Those nanosystems were tested as carriers of a strong chemotherapeutic agent, doxorubicin, which is used against breast cancer. Herein, the magnetic properties of hydrophobic iron oxide nanoparticles located exclusively in the lipid bilayer were used to release this drug from the magnetoliposomes. The cytotoxic activity of the nanostructures against the normal and cancer cell lines was determined on the basis of cells viability measurement after incubation with different concentrations of these nanomaterials. In the same way, the effectiveness of killing cancer cells in combination with exposure to magnetic field was also evaluated. These experiments confirmed that the nanostructures composed of liposomes and magnetic nanoparticles are not cytotoxic. However, magnetoliposomes loaded with doxorubicin were effective and selective in reducing the viability of human breast tumor cell lines. In this paper, we demonstrated the promising application of the studied magnetoliposomes as carriers of doxorubicin released under the influence of magnetic field in tumor cells.
Author Aleksandra Szuplewska (FC / CMB)
Aleksandra Szuplewska,,
- Chair of Medical Biotechnology
, Aleksandra Rękorajska (Joniec)
Aleksandra Rękorajska (Joniec),,
, Edyta Pocztańska (FC / CMB) - Faculty of Chemistry (WChUW) [University of Warsaw (UW)]
Edyta Pocztańska,,
- Chair of Medical Biotechnology
, Paweł Krysiński
Paweł Krysiński,,
, Artur Dybko (FC / CMB)
Artur Dybko,,
- Chair of Medical Biotechnology
, Michał Chudy (FC / CMB)
Michał Chudy,,
- Chair of Medical Biotechnology
Journal seriesNanotechnology, ISSN 0957-4484, (N/A 100 pkt)
Issue year2019
Publication size in sheets0.5
Keywords in Englishdrug delivery system, magnetoliposome, doxorubicin, cytotoxicity
ASJC Classification1502 Bioengineering; 1600 General Chemistry; 2208 Electrical and Electronic Engineering; 2210 Mechanical Engineering; 2211 Mechanics of Materials; 2500 General Materials Science
Languageen angielski
Szuplewska_2019_Nanotechnology_30_315101.pdf 1.94 MB
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 05-02-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.788; WoS Impact Factor: 2018 = 3.399 (2) - 2018=3.403 (5)
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