Preparation of nanostructural dextran-based carrier particles for drug delivery to the lungs

Katarzyna Jabłczyńska , Ewelina Widyńska , Tomasz Robert Sosnowski

Abstract

– Particle engineering can be used to design inhalation drug carrier that will combine advantages of nano- and microparticles. This work present a review of research on dextran- based nanostructural powder prepared using the spray drying method. The shape of powder particles is shown to depend on the applied drying process parameters and additives used. It was proved that surface morphology of particles strongly affects powder aerosolization performance. Tested powders demonstrated a good restoration of the initial nanoparticles size distribution after rehydration. All these features allow to consider dextran- based nanostructural particles as new attractive carriers for drug delivery to the lungs. Work financed by National Science Centre (Poland) - project No. NCN 2014/13/N/ST8/01667.
Author Katarzyna Jabłczyńska KIPZ
Katarzyna Jabłczyńska,,
- Chair of Integrated Process Engineering
, Ewelina Widyńska WIChiP
Ewelina Widyńska,,
- Faculty of Chemical and Process Engineering
, Tomasz Robert Sosnowski KIPZ
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
Pages398-399
Publication size in sheets0.3
Book 6th International Youth Science Forum “Litteris et Artibus”. Proceedings, 2016, Lviv Polytechnic Publishing House, ISBN 978-617-607-988-0, 508 p.LEA-2016_Proceedings.pdf (file archived - login or check accessibility on faculty)
Keywords in Englishnanostructural powder, particle engineering, spray drying, polysaccharide particles, inhalation therapy
Languageen angielski
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Jabłczyńska K. (i in.) - Preparation of nanostructural....pdf (file archived - login or check accessibility on faculty) Jabłczyńska K. (i in.) - Preparation of nanostructural....pdf 1.06 MB
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